87227-21-2Relevant academic research and scientific papers
Cumulated Ylides XX. Syntheses of (E)-α,β-Unsaturated Macrocyclic Lactones by Intramolecular Wittig-Olefination via Triphenylphosphoranylideneketene
Bestmann, Hans Juergen,Schobert, Rainer
, p. 419 - 423 (2007/10/02)
Two methods for closure of macrocyclic lactone rings by intramolecular Wittig reaction of (ω-oxoalkoxy)carbonylmethylenetriphenylphosphoranes are described.The latter are easily accessible by addition of the appropriate (free or protected) ω-hydroxyalkanals to the cumulated ylide triphenylphosphoranylideneketene.Examples are then given for the use of these methods in natural product synthesis.
