872346-89-9Relevant academic research and scientific papers
Synthesis and biological evaluation of a focused library of beauveriolides
Nagai, Kenichiro,Doi, Takayuki,Ohshiro, Taichi,Sunazuka, Toshiaki,Tomoda, Hiroshi,Takahashi, Takashi,Omura, Satoshi
scheme or table, p. 4397 - 4400 (2009/04/06)
Fungal beauveriolide III (1b), discovered as an inhibitor of lipid droplet accumulation in mouse macrophages and showing antiatherogenic activity in mouse model, consists of l-Phe, l-Ala, d-allo-Ile, and (3S, 4S)-3-hydroxy-4-methyloctanoic acid moieties. A combinatorial library of beauveriolide analogues focusing on l-Ala and d-allo-Ile of 1b was synthesized by combinatorial synthesis. Among them, d-Ala analogues consisting of A{2} improved their solubility, while those with 7{1, 3, 2},7{2, 3, 1}, and 7{2, 3, 2} were 20 times more potent than 1b.
Absolute stereochemistry of fungal beauveriolide III and ACAT inhibitory activity of four stereoisomers
Ohshiro, Taichi,Namatame, Ichiji,Nagai, Kenichiro,Sekiguchi, Takafumi,Doi, Takayuki,Takahashi, Takashi,Akasaka, Kazuaki,Rudel, Lawrence L.,Tomoda, Hiroshi,Omura, Satoshi
, p. 7643 - 7649 (2007/10/03)
(Chemical Equation Presented) Fungal beauveriolide III (BeauIII, 1b), a cyclodepsipeptide inhibiting acyl-CoA:cholesterol acyltransferase (ACAT) and showing antiatherogenic activity in mouse models, consists of L-Phe, L-Ala, D-allo-Ile, and 3-hydroxy-4-me
