872357-86-3

Upstream product

• 872357-80-7 (R)-(+)-N,N-dibenzyl-N-[1-cyclohexyl-3-(trimethylsilyl)-2-propynyl]amine 
• 103-49-1 dibenzylamine 
• 2043-61-0 cyclohexanecarbaldehyde 
• 780782-32-3 (±)-N,N-dibenzyl-N-[1-cyclohexyl-3-(trimethylsilyl)-2-propynyl]amine 

Downstream Products

• 872357-94-3 ethyl 4-cyclohexyl-4-(dibenzylamino)-2-butynoate 
• 926622-88-0 (S)-5-cyclohexylpyrrolidin-2-one 
• 19146-53-3 (S)-α-cyclohexylethylamine 

Relevant academic research and scientific papers

Design, preparation, and implementation of an imidazole-based chiral biaryl P,N-ligand for asymmetric catalysis

A new strategy for increasing the barrier to rotation in biaryls has been developed that allows for the incorporation of 5-membered aromatic heterocycles into chiral atropisomers. Using this concept, an imidazole-based biaryl P,N-ligand has been designed and prepared as a single enantiomer. This ligand performs exceptionally well in the enantioselective A3-coupling, demonstrating the potential of this new design element.

Preparation of functionalized primary chiral amines and amides via an enantioselective three-component synthesis of propargylamines

A general preparation of functionalized primary chiral amines and amides from propargylamines has been developed. The chirality is established by an enantioselective three-component reaction of an aldehyde, a terminal alkyne and a secondary amine in the p

Synthesis of chiral α-aminoalkylpyrimidines using an enantioselective three-component reaction

A range of chiral α-aminoalkylpyrimidines has been prepared in a modular fashion in 5 steps with up to 98% ee. The key step is a CuBr-catalyzed enantioselective asymmetric three-component synthesis of propargylic amines.

Practical highly enantioselective synthesis of terminal propargylamines. An expeditious synthesis of (S)-(+)-coniine

The one-pot three-component addition reaction of trimethylsilylacetylene, aldehydes and dibenzylamine provides in the presence of CuBr/Quinap as catalyst, various enantiomerically enriched propargylamines in good yields (up to 99%) and excellent enantiomeric excess (up to 98% ee) which can be used as a key intermediate in the synthesis of the alkaloid (S)-(+)-coniine.