780782-32-3Relevant academic research and scientific papers
Preparation of functionalized primary chiral amines and amides via an enantioselective three-component synthesis of propargylamines
Gommermann, Nina,Knochel, Paul
, p. 11418 - 11426 (2007/10/03)
A general preparation of functionalized primary chiral amines and amides from propargylamines has been developed. The chirality is established by an enantioselective three-component reaction of an aldehyde, a terminal alkyne and a secondary amine in the p
Synthesis of chiral α-aminoalkylpyrimidines using an enantioselective three-component reaction
Dube, Henry,Gommermann, Nina,Knochel, Paul
, p. 2015 - 2025 (2007/10/03)
A range of chiral α-aminoalkylpyrimidines has been prepared in a modular fashion in 5 steps with up to 98% ee. The key step is a CuBr-catalyzed enantioselective asymmetric three-component synthesis of propargylic amines.
