872357-91-0Relevant academic research and scientific papers
Preparation of functionalized primary chiral amines and amides via an enantioselective three-component synthesis of propargylamines
Gommermann, Nina,Knochel, Paul
, p. 11418 - 11426 (2007/10/03)
A general preparation of functionalized primary chiral amines and amides from propargylamines has been developed. The chirality is established by an enantioselective three-component reaction of an aldehyde, a terminal alkyne and a secondary amine in the p
Practical highly enantioselective synthesis of terminal propargylamines. An expeditious synthesis of (S)-(+)-coniine
Gommermann, Nina,Knochel, Paul
, p. 2324 - 2325 (2007/10/03)
The one-pot three-component addition reaction of trimethylsilylacetylene, aldehydes and dibenzylamine provides in the presence of CuBr/Quinap as catalyst, various enantiomerically enriched propargylamines in good yields (up to 99%) and excellent enantiomeric excess (up to 98% ee) which can be used as a key intermediate in the synthesis of the alkaloid (S)-(+)-coniine.
