87236-24-6Relevant academic research and scientific papers
Efficient synthesis of 2-substituted 1-phenylchromen[3,4-d]imidazol-4(1H)-ones with possible anti-inflammatory activity
Balalas, Thomas D.,Gabriel, Catherine,Hadjipavlou-Litina, Dimitra J.,Litinas, Konstantinos E.,Mazaraki, Konstantina,Pontiki, Eleni,Theologis, Asterios K.
, (2020/09/07)
Rare 2-substituted 1-phenylchromeno[3,4-d]imidazol-4(3H)-ones have been synthesized in excellent yields via a two-step reaction mediated by microwave irradiation that involves the reduction of 3-nitro-4-phenylaminocoumarin using H2 and Pd/C to
Simple and efficient copper(I)-catalyzed access to three versatile aminocoumarin-based scaffolds using isocyanoacetate
Meng, Tao,Zou, Yiquan,Khorev, Oleg,Jin, Yu,Zhou, Huayong,Zhang, Yongliang,Hu, Dingyu,Ma, Lanping,Wang, Xin,Shen, Jingkang
supporting information; experimental part, p. 918 - 924 (2011/06/21)
An efficient method has been developed for the one-pot copper(I)-catalyzed synthesis of 3-aminocoumarin and its derivatives, such as 3-substituted methylideneaminocoumarins and chromeno[3,4-d]imidazol-4(1H)-ones. Significantly, the strategy presents a straightforward and efficient approach to constructing biologically useful molecular scaffolds.
IMIDAZOLE DERIVATIVES AS PHOSPHODIESTERASE VII INHIBITORS
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, (2008/06/13)
The invention relates to imidazole derivatives of formula (I), wherein R means H, A, benzyl, indane-5-yl, 1,2,3,4-tetrahydro-naphthaline-5-yl, dibenzothiophene-2-yl or phenyl that is unsubstituted or substituted once, twice or three times by means of Hal, A, A-CO-NH, benzyloxy, alkoxy, COOH or COOA, R means H or A, X means O or S, Hal means F, Cl, Br or I and A means alkyl with 1 to 6 C-atoms. The invention also relates to the physiologically acceptable salts and/or solvates thereof acting as phosphodiesterase VII inhibitors. The invention further relates to the use thereof for producing a medicament.
