872360-01-5Relevant academic research and scientific papers
Discovery of N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 antagonists with improved pharmacological profile
Ceccarelli, Simona M.,Pinard, Emmanuel,Stalder, Henri,Alberati, Daniela
, p. 354 - 357 (2007/10/03)
During SAR exploration of N-(2-aryl-cyclohexyl) substituted spiropiperidine as GlyT1 inhibitors, it was found that introduction of an hydroxy group in position 2 of the cyclohexyl residue considerably improves the pharmacological profile. In particular, r
