872360-66-2

Upstream product

• 1454797-15-9 (2S,3R,4R,5S)-1-benzyl-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-5-(trityloxymethyl)-pyrrolidine 
• 1454797-13-7 (2R,3S,4S,5S)-1,3,4-tris(benzyloxy)-6-(trityloxy)hexane-2,5-diyl dimethanesulfonate 
• 100-46-9 benzylamine 
• 1454797-11-5 (2R,3R,4R,5S)-1,3,4-tris(benzyloxy)-6-(trityloxy)hexane-2,5-diol 
• 1454797-09-1 (2R,3R,4S)-1,3,4-tris(benzyloxy)-5-oxo-6-(trityloxy)hexan-2-yl formate 
• 151507-95-8 (2S,3R,4R,5S)-N-benzyl-3,4-dibenzyloxy-5-[(benzyloxy)methyl]-2-vinyl-pyrrolidine 

Downstream Products

• 1454797-21-7 ((2S,3R,4S,5S)-1-benzyl-3,4-bis(benzyloxy)-5-(benzyloxymethyl)-pyrrolidin-2-yl)methyl 4-nitrobenzoate 
• 105015-44-9 (2S,3R,4R,5S)-3,4-dihydroxy-2,5-bis(hydroxymethyl)pyrrolidine 

Relevant academic research and scientific papers

Synthesis of dihydroxymethyl dihydroxypyrrolidines and steviamine analogues from C-2 formyl glycals

Synthesis of dihydroxymethyl dihydroxypyrrolidines from C-2 formyl d-glycals has been described via a common dicarbonyl intermediate. The hence obtained pyrrolidines have been further utilized for the synthesis of some steviamine analogues. The newly synthesized molecules have been evaluated for glycosidase inhibition against 6 commercially available enzymes and found to be active in the micromolar range, where one of the steviamine analogues showed good and selective inhibition of β-mannosidase (Helix pomatia).

Iminosugars as glycosyltransferase inhibitors: Synthesis of polyhydroxypyrrolidines and their evaluation on chitin synthase activity

Chitin synthase is an enzyme involved in the biosynthesis of chitin, a major structural component of the cell wall of many fungi. Since chitin is absent in vertebrates, chitin synthase has been envisaged as a valuable target in the search for new antifung