872368-73-5

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 817-87-8 ethyl azidocarbonate 
• 1427026-26-3 1-(4-methylbenzenesulfonyl)-4-(4-fluorobenzene)-1H-1,2,3-triazole 
• 4648-54-8 trimethylsilylazide 
• 75-52-5 nitromethane 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 915727-99-0 4-(4-fluorophenyl)-2-phenyl-2H-1,2,3-triazole 
• 1305196-70-6 2-(4-chlorophenyl)-4-(4-fluorophenyl)-2H-1,2,3-triazole 
• 1305196-69-3 2,4-bis(4-fluorophenyl)-2H-1,2,3-triazole 
• 1305196-71-7 4-(4-fluorophenyl)-2-(4-methoxyphenyl)-2H-1,2,3-triazole 
• 1305196-68-2 4-(4-(4-fluorophenyl)-2H-1,2,3-triazol-2-yl)benzonitrile 

Relevant academic research and scientific papers

Cycloaddition of: N -sulfonyl and N -sulfamoyl azides with alkynes in aqueous media for the selective synthesis of 1,2,3-triazoles

The cycloaddition of N-sulfonyl and N-sulfamoyl azides with terminal alkynes generally produces amide derivatives via ketenimine intermediates. We herein delineate a Cu(i) catalyzed method using a prolinamide ligand that selectively generates N-sulfonyl a

A [3+2] cycloaddition-1,2-acyl migration-hydrolysis cascade for regioselective synthesis of 1,2,3-triazoles in water

A cascade sequence involving [3+2] cycloaddition, 1,2-acyl migration and hydrolysis produces 2H-1,2,3-triazolesviathe regioselective formation ofN2-carboxyalkylated triazoles. The reaction proceeds in aqueous media through intriguing reaction kinetics using a CuI-prolinamide catalyst system. Prolinamide promotes the novel organocatalytic 1,2-acyl migration as well as hydrolysis of the resultingN2-carboxyalkylated triazoles.

Catalyst-Free Regioselective N2 Arylation of 1,2,3-Triazoles Using Diaryl Iodonium Salts

The widespread application of 1,2,3-triazoles in pharmaceuticals has resulted in substantial interest toward developing efficient postmodification methods. Whereas there are many postmodification methods available to obtain N1-substituted 1,2,3-triazoles, developing a selective and convenient protocol to synthesize N2-aryl-1,2,3-triazoles has been challenging. We report a catalyst-free and regioselective method to access N2-aryl-1,2,3-triazoles in good to excellent yields (66-97%). This scalable postmodification protocol is effective for a wide range of substrates.

Catalyst and solvent free microwave-assisted synthesis of substituted 1,2,3-triazoles

We report a microwave-assisted catalyst and solvent free synthesis of 1,2,3-triazoles through the cycloaddition of trimethylsilylazide and acetylenes. Utilization of a thermally stable azide source, elimination of a metal catalyst, solvent or any additives, and a convenient isolation procedure result in an overall greener approach to access 1,2,3-triazoles on a practical scale with good to excellent yields (55-99%).

p-Toluenesulfonic acid-promoted autocatalytic hydrolyzation of 1-tosyl-1,2,3-triazoles

The first example of autocatalytic hydrolyzation of 4-aryl-1-tosyl-1,2,3-triazoles induced by p-toluenesulfonic acid was reported, providing an effective and metal-free synthetic approach to deliver a broad range of new 4-aryl-2H-1,2,3-triazoles in good yields. The kinetic profile of this hydrolyzation suggested that this reaction has exponential autocatalytic behavior.

A NH - 1, 2, 3 - triazole synthetic method

The invention discloses a method for synthesizing NH-1,2,3-triazole shown by a formula (I). Under the catalytic action of a Lewis acid catalyst, nitroalkene shown by a formula (II) and hydrazoic acid salt undergo 1,3-dipolar cycloaddition, wherein Ar is p

Aluminium(III) Chloride-Catalyzed Three-Component Condensation of Aromatic Aldehydes, Nitroalkanes and Sodium Azide for the Synthesis of 4-Aryl-NH-1,2,3-triazoles

An aluminium(III) chloride-catalyzed three-component reaction of aromatic aldehydes, nitroalkanes, and sodium azide has been developed; this reaction sequence can be applied to a broad substrate scope and affords the corresponding 4-aryl-NH-1,2,3-triazoles in good to excellent yields. The milder reaction conditions and easier operation make this AlCl3-catalyzed protocol more advantageous for the synthesis of 4-aryl-NH-1,2,3-triazoles. (Figure presented.).

Structure-activity relationship and enzyme kinetic studies on 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase (IDO) inhibitors

Previously, we have reported the design and synthesis of 4-aryl-1H-1,2,3-triazoles as inhibitors of indoleamine 2,3-dioxygenase (IDO), a promising therapeutic target of cancer. Here, we present the structure-activity relationship and enzyme kinetic studie