872406-68-3Relevant academic research and scientific papers
Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1b converting enzyme inhibitors
O'Neil, Steven V.,Wang, Yili,Laufersweiler, Michael C.,Oppong, Kofi A.,Soper, David L.,Wos, John A.,Ellis, Christopher D.,Baize, Mark W.,Bosch, Gregory K.,Fancher, Amy N.,Lu, Wei,Suchanek, Maureen K.,Wang, Richard L.,De, Biswanath,Demuth Jr., Thomas P.
, p. 5434 - 5438 (2005)
Two novel 8,6-fused bicyclic peptidomimetic ring systems were synthesized utilizing olefin metathesis as the key reaction for the formation of the eight-membered ring. Both peptidomimetic scaffolds were further elaborated into potent ICE inhibitors, with
