Bioorganic and Medicinal Chemistry Letters p. 5434 - 5438 (2005)
Update date:2022-08-02
Topics:
O'Neil, Steven V.
Wang, Yili
Laufersweiler, Michael C.
Oppong, Kofi A.
Soper, David L.
Wos, John A.
Ellis, Christopher D.
Baize, Mark W.
Bosch, Gregory K.
Fancher, Amy N.
Lu, Wei
Suchanek, Maureen K.
Wang, Richard L.
De, Biswanath
Demuth Jr., Thomas P.
Two novel 8,6-fused bicyclic peptidomimetic ring systems were synthesized utilizing olefin metathesis as the key reaction for the formation of the eight-membered ring. Both peptidomimetic scaffolds were further elaborated into potent ICE inhibitors, with
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