872409-95-5Relevant academic research and scientific papers
ANTIBODY-DRUG CONJUGATES
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Paragraph 0189; 0190, (2018/05/26)
An antibody-drug conjugate (ADC) has a structure represented by Formula (I): [in-line-formulae][D2-L2-Cn2?yG2-Ab-Sg1?G1-L1-D1]x?? Formula (I)[/in-line-formulae]or a pharmaceutically acceptable salt thereof, wherein Ab is an antibody without glycans (i.e., the protein portion of an antibody);G1 and G2 are glycan moieties, which may be the same or different;Cn1 and Cn2 are conjugation moieties, which may be the same or different;L1 and L2 are linker moieties, which may be the same or different;D1 and D2 are drug units which may be the same or different; andx and y are independently an integer from 0 to 8, provided that x+y≠0.
Carbohydrate rod conjugates: Ternary rod-coil molecules forming complex liquid crystal structures
Chen, Bin,Baumeister, Ute,Pelzl, Gerhard,Das, Malay Kumar,Zeng, Xiangbing,Ungar, Goran,Tschierske, Garsten
, p. 16578 - 16591 (2007/10/03)
T-shaped polyphilic triblock molecules, consisting of a rodlike p-terphenyl unit, a hydrophilic and flexible laterally attached oligo(oxyethylene) chain terminated by an 1-acylamino-1-deoxy-D-sorbitol unit, and two end-attached lipophilic alkyl chains, have been synthesized by palladium-catalyzed cross-coupling reactions as the key steps. The thermotropic liquid crystalline behavior of these compounds was investigated by polarized light microscopy, differential scanning calorimetry (DSC), and X-ray scattering. We investigated the mode of self-organization as a function of the length and position of the lateral polar chain and the length of the terminal alkyl chains. Depending on the size of the polar and lipophilic segments, a series of unusual liquid crystalline phases was detected. In three of these phases, the space is divided into three distinct periodic subspaces. In addition to a hexagonal channeled layer phase (ChLhex) consisting of layers that are penetrated by polar columns, there are also two honeycomb-like network structures formed by square (Colsqu/p4mm) or pentagonal cylinders (Colsqu/p4gm) . The cylinder walls consist of the terphenyl units fused by columns of alkyl chains, and the interior contains the polar side chains. In addition, a hexagonal columnar phase was observed in which the polar columns are organized in a continuum of terphenyls and alkyl chains with an organization of the terphenyl cores tangentially around the columns with the long axis perpendicular to the columns. For one compound, a reversal of birefringence was observed, which is explained by a reorientation of the terphenyl cores. The addition of protic solvents induces lamellar phases.
Supramolecular dendrimers: Unusual mesophases of ionic liquid crystals derived from protonation of DAB dendrimers with facial amphiphilic carboxylic acids
Cook, Andrew G.,Baumeister, Ute,Tschierske, Carsten
, p. 1708 - 1721 (2008/12/20)
Supramolecular liquid crystalline (LC) dendrimers were prepared by self-assembly of first to fifth generation amino terminated DAB dendrimers with facial amphiphilic carboxylic acids. These carboxylic acids are composed of three distinct incompatible segm
