51951-04-3

Basic information

• Product Name: Hydroxy-PEG2-CH2CO2H
• Synonyms: Hydroxy-PEG2-CH2CO2H;Hydroxy-PEG2-CH2COOH;HO-PEG2-CH2COOH;[2-(2-Hydroxyethoxy)ethoxy]acetic acid;OH-PEG2-CH2COOH;PEG2-CH2COOH;Hydroxy-PEG2-CH2CO2H, sodium salt;8-hydroxy-3,6-dioxaoctanoic acid
• CAS NO: 51951-04-3
• Molecular Formula: C₆H₁₂O₅
• Molecular Weight: 164.15648
• Mol File: 51951-04-3.mol

Chemical Properties

• Boiling Point: 343.4±22.0 °C(Predicted)
• Appearance: /
• Density: 1.239±0.06 g/cm3(Predicted)
• PKA: 3.39±0.10(Predicted)
• CAS DataBase Reference: Hydroxy-PEG2-CH2CO2H(CAS DataBase Reference)
• NIST Chemistry Reference: Hydroxy-PEG2-CH2CO2H(51951-04-3)
• EPA Substance Registry System: Hydroxy-PEG2-CH2CO2H(51951-04-3)

Safety Data

• Hazardous Substances Data: 51951-04-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Hydroxy-PEG2-CH2CO2H is used as a PEG linker for the preparation of cyclin-dependent kinase inhibitors, which are crucial in the treatment of various types of cancer. The hydrophilic PEG spacer increases the solubility of the drug in aqueous media, improving its bioavailability and therapeutic effectiveness.
Used in Chemical Synthesis:
In the field of chemical synthesis, Hydroxy-PEG2-CH2CO2H sodium salt serves as a versatile building block for the creation of various PEGylated compounds. The terminal carboxylic acid allows for the formation of stable amide bonds with primary amine groups, enabling the synthesis of a wide range of PEGylated molecules with potential applications in drug delivery, diagnostics, and other biomedical fields.
Used in Drug Delivery Systems:
Hydroxy-PEG2-CH2CO2H is utilized as a component in the development of drug delivery systems, particularly for enhancing the solubility and bioavailability of hydrophobic drugs. The hydrophilic PEG spacer can improve the stability and circulation time of drug molecules in the bloodstream, leading to more effective drug delivery and reduced side effects.
Used in Diagnostics:
In the diagnostics industry, Hydroxy-PEG2-CH2CO2H can be employed for the development of PEGylated contrast agents or imaging probes. The hydrophilic nature of the PEG spacer can enhance the solubility of these agents in aqueous environments, improving their performance in medical imaging techniques such as magnetic resonance imaging (MRI) or computed tomography (CT) scans.
Overall, Hydroxy-PEG2-CH2CO2H sodium salt is a versatile and valuable compound in various industries, particularly in the pharmaceutical, chemical synthesis, drug delivery, and diagnostics sectors, due to its unique properties and potential for further derivatization.

Upstream product

• 3926-62-3 sodium monochloroacetic acid 
• 111-46-6 diethylene glycol 

Downstream Products

• 872410-09-8 methyl 8-(4,4''-didecyloxy-p-terphenyl-2'-yloxy)-3,6-dioxaoctanoate 
• 872410-02-1 methyl 8-(4,4''-dibutyloxy-p-terphenyl-2'-yloxy)-3,6-dioxaoctanoate 
• 872409-95-5 methyl 8-(4-toluenesulfonyloxy)-3,6-dioxaoctanoate 
• 872409-99-9 methyl 8-(2,5-dichlorophenyloxy)-3,6-dioxaoctanoate 

Relevant articles and documents

Carbohydrate rod conjugates: Ternary rod-coil molecules forming complex liquid crystal structures

T-shaped polyphilic triblock molecules, consisting of a rodlike p-terphenyl unit, a hydrophilic and flexible laterally attached oligo(oxyethylene) chain terminated by an 1-acylamino-1-deoxy-D-sorbitol unit, and two end-attached lipophilic alkyl chains, have been synthesized by palladium-catalyzed cross-coupling reactions as the key steps. The thermotropic liquid crystalline behavior of these compounds was investigated by polarized light microscopy, differential scanning calorimetry (DSC), and X-ray scattering. We investigated the mode of self-organization as a function of the length and position of the lateral polar chain and the length of the terminal alkyl chains. Depending on the size of the polar and lipophilic segments, a series of unusual liquid crystalline phases was detected. In three of these phases, the space is divided into three distinct periodic subspaces. In addition to a hexagonal channeled layer phase (ChLhex) consisting of layers that are penetrated by polar columns, there are also two honeycomb-like network structures formed by square (Colsqu/p4mm) or pentagonal cylinders (Colsqu/p4gm) . The cylinder walls consist of the terphenyl units fused by columns of alkyl chains, and the interior contains the polar side chains. In addition, a hexagonal columnar phase was observed in which the polar columns are organized in a continuum of terphenyls and alkyl chains with an organization of the terphenyl cores tangentially around the columns with the long axis perpendicular to the columns. For one compound, a reversal of birefringence was observed, which is explained by a reorientation of the terphenyl cores. The addition of protic solvents induces lamellar phases.

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