872415-39-9Relevant academic research and scientific papers
Gold- and Br?nsted Acid-Catalysed Deacyloxylative Cycloaromatisation of 1,6-Diyne Esters to 11H-Benzo[a]fluorenes and 13H-Indeno[1,2-l]phenanthrenes
Baratay, Corentin Antoine,Li, Wenhai,Mathiew, Mitch,Yu, Lei,Kyne, Sara Helen,Rao, Weidong,Chan, Philip Wai Hong
, p. 1313 - 1318 (2022/03/15)
A synthetic method to prepare 11H-benzo[a]fluorenes and 13H-indeno[1,2-l]phenanthrenes that relies on the gold(I)- and Br?nsted acid-mediated deacyloxylative cycloaromatisation of 1,6-diyne esters under reaction conditions that did not require the exclusion of moisture or air is described. The reaction mechanism was delineated to involve an initial gold(I)-catalysed 1,2-acyloxy migration and 5-exo-trig cyclisation pathway. This was followed by 1,5-enyne rearrangement and Br?nsted acid-assisted deacyloxylative aromatisation to give the polyaromatic hydrocarbon (PAH) product. (Figure presented.).
Indole derivatives comprising an acetylene group
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Page/Page column 27, (2008/06/13)
This invention is directed to compounds of the formula (I): wherein one of R6, R7, R8 and R9 is and X, R1 to R12, m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention is also directed to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
Phenyl derivatives comprising an acetylene group
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Page/Page column 31, (2010/02/15)
This invention is concerned with compounds of the formula I: wherein one of R5, R6 and R7 is and X1, X2, R1 to R12, m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
