87243-12-7Relevant academic research and scientific papers
REACTIONS OF 4,5-DINITROIMIDAZOLE AND 4(5)-NITROIMIDAZOLE-5(4)-SULFONIC ACID WITH NUCLEOPHILES
Mokrushin, V. S.,Belyaev, N. A.,Kolobov, M. Yu.,Fedotov, A. N.
, p. 650 - 652 (1983)
The reactions of 4,5-dinitroimidazole and 5(4)-nitroimidazole-4(5)-sulfonic acid with nucleophilic agents were studied.Mercapto-, alkoxy-, and aminonitroimidazoles were synthesized.In the reaction of dinitroimidazole with sodium alkoxides 5(4)-nitroimidazole was obtained in addition to alkoxynitroimidazoles.It is shown that in the formation of salts of the starting imidazoles with bases nucleophilic-substitution reactions take place only with "soft" reagents.
Synthesis, anti-HIV-1 and antiproliferative evaluation of novel 4-nitroimidazole derivatives combined with 5-hydroxy-4-pyridinone moiety
Shirvani, Pouria,Fassihi, Afshin,Saghaie, Lotfollah,Van Belle, Siska,Debyser, Zeger,Christ, Frauke
, (2019/11/26)
In an effort to synthesize more effective non-nucleoside reverse transcriptase inhibitors (NNRTIs) against the HIV-1 infection, a new series of novel 4-nitroimidazole derivatives combined with 5-hydroxy-4-pyridinone moiety were designed by molecular docking studies, prepared and characterized by spectroscopic techniques. All the synthesized compounds were in vitro evaluated for their inhibitory effect against the HIV-1 replication in the MT-4 cells. Results showed that none of these synthesized compounds displayed any specific anti HIV-1 activity. Surprisingly, these compounds showed high cytotoxicity against MT-4 cells with low selectivity index (50 = 1.3 μM and EC50 = 1.8 μM respectively).
RING TRANSFORMATION REACTIONS IN 4-NITROIMIDAZOLES FOLLOWING AN ATTACK OF NUCLEOPHILES
Suwinski, Jerzy,Pawlus, Wojciech,Salwinska, Ewa,Swierczek, Krzysztof
, p. 1511 - 1520 (2007/10/02)
It was proved that 4-nitroimidazoles substituted at the nitrogen atom 1 with electron acceptor groups (aryl, arenesulfonyl, nitro) in reactions with some nucleophiles yield the products of ordinary or degenerated imidazole ring transformation (oxadiazoles, triazoles, imidazoles).
