87243-48-9

Basic information

• Product Name: 3-Pyridinecarbonitrile, 1,2-dihydro-2-oxo-4-[(phenylmethyl)amino]-
• CAS NO: 87243-48-9
• Molecular Formula: C13H11N3O
• Molecular Weight: 225.25
• Mol File: 87243-48-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarbonitrile, 1,2-dihydro-2-oxo-4-[(phenylmethyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarbonitrile, 1,2-dihydro-2-oxo-4-[(phenylmethyl)amino]-(87243-48-9)
• EPA Substance Registry System: 3-Pyridinecarbonitrile, 1,2-dihydro-2-oxo-4-[(phenylmethyl)amino]-(87243-48-9)

Safety Data

• Hazardous Substances Data: 87243-48-9(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 87243-45-6 α-Cyano-β-N-benzylaminocrotonamide 
• 62321-92-0 α-cyano-β-dimethylaminocrotonamide 
• 87243-46-7 1-Benzyl-4-oxo-5-cyano-6-(β-N,N-dimethylaminovinyl)-1,4-dihydropyrimidine 

Downstream Products

• 87243-49-0 2-Chloro-3-cyano-4-N-benzylaminopyridine 
• 87243-50-3 2-Amino-3-cyano-4-N-benzylaminopyridine 
• 103589-59-9 4-Benzylamino-2-(3-isopropyl-2-phenyl-oxazolidin-5-ylmethoxy)-nicotinonitrile 

Relevant articles and documents

ACETALS OF LACTAMS AND ACID AMIDES. 47.* INVESTIGATION OF THE BEHAVIOR OF SUBSTITUTED 6-(β-DIMETHYLAMINO)VINYL-4-PYRIMIDINONES IN ACID MEDIA. SYNTHESIS OF 3-CYANO-4-ANILINO-5-FORMYL-2-PYRIDONE AND 3-CHLORO-4-CYANOBENZONAPHTHYRIDINE

The hydrolysis of 1-substituted 5-cyano-6-(β-dimethylamino)vinyl-4-pyrimidinones in acidic media was studied.It was shown that the 1-benzyl derivative is converted to a mixture of α-cyano-4β-benzylamino-crotonamide and 3-cyano- and 3-carbamido-4-benzyl-amino-2-pyridones.The principal product in the hydrolysis of the 1-phenyl derivative is 3-cyano-4-anilino-5-formyl-2-pyridone.Cyclization of the latter by heating in phosphorus oxychloride leads to 3-chloro-4-cyanobenzonaphthyridine.

ACETALS OF LACTAMS AND ACID AMIDES. 38. SYNTHESIS OF PYRIMIDINE AND PYRIDINE DERIVATIVES ON THE BASIS OF THE REACTION OF ENAMINO AMIDES WITH AMIDE ACETALS

Derivatives of 1-benzyl-4-pyrimidinones and 1-benzyl-6-pyrimidinones were synthesized by the reaction of α-cyano-β-N-benzylaminocrotonamide and α-cyano-β-aminocrotonic acid N-benzylamine with dimethylformamide diethylacetal.When 1-benzyl-5-cyano-6-(β-dimethylamino)vinyl-1,6-dihydro-4-pyrimidinone is heated in an alkaline medium, it is converted to 3-cyano-4-benzylamino-2-pyridone, from which a pyridopyrimidine derivative was synthesized.When 1-benzyl-5-cyano-4-(β-dimethylamino)vinyl-1,6-dihydro-6-pyrimidinone is heated in alkaline solution, it is converted to α-cyano-β-hydroxycrotonic acid N-benzylamide.