87252-81-1Relevant academic research and scientific papers
Approach to Fully Substituted Cyclic Nitrones from N-Hydroxylactam Derivatives: Development and Application to the Total Synthesis of Cylindricine C
Hiraoka, Shobu,Matsumoto, Tsutomu,Matsuzaka, Koki,Sato, Takaaki,Chida, Noritaka
supporting information, p. 4381 - 4385 (2019/02/26)
An approach to cyclic nitrones from N-hydroxylactam derivatives is documented. The nucleophilic addition of an organolithium reagent to an N-OSEM [SEM=2-(trimethylsilyl)ethoxymethyl] lactam forms a five-membered chelated intermediate, which undergoes both elimination and deprotection to give a fully substituted nitrone in a one-pot process. When combined with the N-oxidation of easily available chiral lactams, this method becomes especially useful for the quick synthesis of chiral nitrones in enantio-pure form, enabling the concise total synthesis of cylindricine C.
Enzymatic synthesis of chiral γ-amino acids using ω-transaminase
Shon, Minsu,Shanmugavel, Ramachandran,Shin, Giyoung,Mathew, Sam,Lee, Sang-Hyeup,Yun, Hyungdon
supporting information, p. 12680 - 12683 (2015/05/20)
In this study, we successfully synthesized enantiomerically pure (R)- and (S)-γ-amino acids (>99% ee) using ω-transaminase (ω-TA) through kinetic resolution and asymmetric synthesis respectively. The present study demonstrates the high potentiality of ω-TA reaction for the production of chiral γ-amino acids.
FACTOR XA INHIBITORS
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Page 54, (2010/02/07)
Compounds of formula (I) in which R1, n, Z, R3 and R4 have any of the meanings given in the specification, are inhibitors of the serine protease Factor Xa and are useful in the treatment of thrombotic disorders.
Structures of 4-Hydroxyimino-4-phenylbutanoic Acid, C10H11NO3 (I), and 5-Hydroxyimino-5-phenylpentanoic Acid, C11H13NO3 (II), at 223 K
Maurin, Jan K.,Paul, Iain C.,Curtin, David Y.
, p. 78 - 81 (2007/10/02)
Infinite polar chains of molecules with strong intermolecular hydrogen bonds (O-H...N and O-H...O) are observed between carboxyl and oxime groups N...O 2.697(1) and O...O 2.784(1) Angstroem for (I), and 2.690(2) and 2.744(2) Angstroem for (II), respectiv
