872544-47-3

Upstream product

• 872544-45-1 (S)-4-(4-Fluoro-phenyl)-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester 
• 923932-21-2 (-)-(3S,4R)-4-(4-fluoro-phenyl)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 
• 923932-19-8 (3S,4R)-4-(4-fluorophenyl)-3-formylpiperidine-1-carboxylic acid tert-butyl ester 
• 200572-33-4 (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester 
• 125224-43-3 (3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine 
• 609341-05-1 (R)-5-benzoylamino-2-cyano-3-(4-fluorophenyl)-5-oxopentanoic acid methyl ester 
• 609340-96-7 N-[3-(4-fluorophenyl)acryloyl]benzamide 
• 459-57-4 4-fluorobenzaldehyde 
• 230309-03-2 (4S)-(4-phenyl-2-thioxo-1,3-diazolidin-3-yl)-pyridin-3-yl-methanone 
• 1493-23-8 (4-fluorophenyl)lithium 
• 872544-56-4 [(S)-1-Benzoyl-4-(4-fluoro-phenyl)-1,4-dihydro-pyridin-3-yl]-((S)-4-phenyl-2-thioxo-thiazolidin-3-yl)-methanone 
• 872544-44-0 (S)-4-(4-Fluoro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester 
• 609341-34-6 (R)-4-(4-Fluoro-phenyl)-6-oxo-piperidine-3-carboxylic acid methyl ester 

Downstream Products

• 200572-35-6 (3S,4R)-1-(tert-butoxycarbonyl)-4-(p-fluorophenyl)-3-[3,4-(methylenedioxy)phenoxymethyl]piperidine 
• 200572-34-5 (3S,4R)-tert-butyl 4-(4-fluorophenyl)-3-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate 
• 200572-33-4 (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester 
• 110429-35-1 (-)-paroxetine hydrochloride 
• 125224-43-3 (3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine 

Relevant academic research and scientific papers

CCR2 MODULATORS

Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I) and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of CCR2 receptors.

A new route to 3,4-disubstituted piperidines: Formal synthesis of (-)-paroxetine and (+)-femoxetine

A new route to 3,4-disubstituted piperidines was developed using chiral 1,4-dihydropyridines as key intermediates, the synthetic utility of which was demonstrated by formal synthesis of (-)-paroxetine and (+)-femoxetine.

Enantioselective Michael additions to α,β-unsaturated imides catalyzed by a salen-al complex

(Salen)aluminum complex 1b is an efficient catalyst for the conjugate addition of di- and trisubstituted nitriles to a wide range of acyclic alkyl- and aryl-substituted α,β-unsaturated imides. This new methodology provides access to multifunctional compounds that previously have not been readily accessible in enantioenriched form. Synthetic applications of these products include the preparation of enantiomerically enriched piperidines, as exemplified by an expedient asymmetric catalytic synthesis of (-)-paroxetine. Copyright