923932-21-2

Basic information

• Product Name: 1,3-Piperidinedicarboxylic acid, 4-(4-fluorophenyl)-, 1-(1,1-dimethylethyl) ester, (3S,4R)-
• CAS NO: 923932-21-2
• Molecular Formula: C17H22FNO4
• Molecular Weight: 323.364
• Mol File: 923932-21-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,3-Piperidinedicarboxylic acid, 4-(4-fluorophenyl)-, 1-(1,1-dimethylethyl) ester, (3S,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Piperidinedicarboxylic acid, 4-(4-fluorophenyl)-, 1-(1,1-dimethylethyl) ester, (3S,4R)-(923932-21-2)
• EPA Substance Registry System: 1,3-Piperidinedicarboxylic acid, 4-(4-fluorophenyl)-, 1-(1,1-dimethylethyl) ester, (3S,4R)-(923932-21-2)

Safety Data

• Hazardous Substances Data: 923932-21-2(Hazardous Substances Data)

Usage

Molecular weight

329.39 g/mol

Appearance

White crystalline powder

Stereochemistry

(3S,4R)-

Parent compound

1,3-Piperidinedicarboxylic acid

Substituents

a. 4-(4-fluorophenyl) group
b. 1-(1,1-dimethylethyl) ester group

Biological activity

Modulator of neurotransmitter receptors

Applications

a. Building block in the synthesis of pharmaceutical and agrochemical products
b. Potential use in the development of new medications for neurological disorders
c. Reagent in organic synthesis and medicinal chemistry research

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 200572-33-4 (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester 
• 125224-43-3 (3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine 
• 951167-04-7 (+)-(3R,4R)-4-(4-fluoro-phenyl)-piperidine-1,3-dicarboxylic acid 1-tert butyl ester 3-methyl ester 
• 923932-19-8 (3S,4R)-4-(4-fluorophenyl)-3-formylpiperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 872544-47-3 (3S,4R)-4-(4-fluorophenyl)piperidine-3-carboxylic acid methyl ester 
• 200572-33-4 (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

CCR2 MODULATORS

Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I) and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of CCR2 receptors.

Process for the preparation of enantiomerically enriched cyclic beta-aryl or heteroaryl carbocyclic acids

The present invention relates to a process for the preparation of cis substituted cyclic β-aryl or heteroaryl carboxylic acid derivatives in high diastereo- and enantioselectivity by enantioselective hydrogenation in accordance with the following scheme w

NOVEL BENZO [D] [1,3]-DIOXOL DERIVATIVES

The present invention relates to an isotopologue of Compound 1 substituted with deuterium at the methylene carbon of the benzodioxol ring. The isotopologues of this invention selective serotonin reuptake inhibitors (SSRIs) and possess unique biopharmaceutical and metabolic properties compared to Compound 1. They may also be used to accurately determine the concentration of Compound 1 in biological fluids and to determine metabolic patterns of Compound 1 and its isotopologues. The invention further provides compositions comprising these deuterated isotopologues and methods of treating diseases and conditions that are responsive to increased neuronal serotonin transmission, alone and in combination with additional agents.