872550-36-2Relevant academic research and scientific papers
Iodine-Mediated Cyclization of ortho-Alkynylaryl Ketones for the Synthesis of Indenone Derivatives
Chuangsoongnern, Pennapa,Surinrach, Chareef,Tummatorn, Jumreang,Thongsornkleeb, Charnsak,Ruchirawat, Somsak
, p. 5102 - 5109 (2017/09/23)
A new method for the synthesis of indenone derivatives based on the I2-promoted cyclization of ortho-alkynylaryl ketones has been developed. This method provides a metal-free and convenient route for the regioselective synthesis of indenones using ortho-alkynylaryl ketones with predefined substituents to give indenone products in moderate to good yields.
Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands
Fang, Jing,Akwabi-Ameyaw, Adwoa,Britton, Jonathan E.,Katamreddy, Subba R.,Navas III, Frank,Miller, Aaron B.,Williams, Shawn P.,Gray, David W.,Orband-Miller, Lisa A.,Shearin, Jean,Heyer, Dennis
scheme or table, p. 5075 - 5077 (2009/05/07)
A series of estrogen receptor ligands based on a 3-alkyl naphthalene scaffold was synthesized using an intramolecular enolate-alkyne cycloaromatization as the key step. Several of these compounds bearing a C6-OH group were shown to be high affinity ligand
CHEMICAL COMPOUNDS
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Page/Page column 95-96, (2010/02/15)
The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel naphthalene compounds that are particularly useful for selective estrogen receptor modulation.
