36081-66-0

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-BROMOPHENYL)-2-PHENYLETHAN-1-ONE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of various medicinal compounds.
Used in Agrochemical Industry:
1-(2-BROMOPHENYL)-2-PHENYLETHAN-1-ONE is used as a key intermediate in the synthesis of agrochemicals, playing a crucial role in the production of pesticides.
Used in Fragrance Industry:
1-(2-BROMOPHENYL)-2-PHENYLETHAN-1-ONE is used as a key intermediate in the synthesis of fragrances, contributing to the creation of various scented compounds.
It is important to handle 1-(2-BROMOPHENYL)-2-PHENYLETHAN-1-ONE with caution as it is a potentially hazardous substance. Safe usage and storage practices are essential to prevent any adverse effects.

InChI:InChI=1/C14H11BrO/c15-13-9-5-4-8-12(13)14(16)10-11-6-2-1-3-7-11/h1-9H,10H2

Upstream product

• 693208-77-4 2-Bromphenylbenzyl-ketimin 
• 21375-88-2 1-bromo-2-(phenylethenyl)benzene 
• 2042-37-7 o-cyanobromobenzene 
• 583-55-1 1-Bromo-2-iodobenzene 
• 536-74-3 phenylacetylene 
• 140-29-4 phenylacetonitrile 
• 244205-40-1 (2-bromophenyl)boronic acid 
• 18982-54-2 o-bromobenzyl alcohol 
• 1589-82-8 phenylmagnesium bromide 
• 7154-66-7 2-bromobenzoic acid chloride 
• 100-39-0 benzyl bromide 
• 88-65-3 2-bromobenzoic-acid 
• 62673-31-8 benzyl(bromo)zinc 
• 5411-56-3 1-(2-bromophenyl)ethanol 

Downstream Products

• 430429-44-0 (Z)-1-(2-bromophenyl)-2-phenyl-1-ethanone oxime 
• 575-61-1 Isoaurone 
• 451-40-1 phenyl benzyl ketone 
• 4001-73-4 2-Bromobenzamide 
• 77989-10-7 3-o-bromophenyl-4-phenyl-1,2,5-thiadiazole 
• 77989-15-2 2-(4’,6’-diphenyl-1’,3’,5’-triazinyl)bromobenzene 
• 40523-32-8 3-(phenylmethylene)isoindol-1-one 
• 1258792-41-4 1,3-diphenylquinolin-4(1H)-one 
• 1258792-42-5 1-(4-methoxyphenyl)-3-phenylquinolin-4(1H)-one 
• 1258792-43-6 3-phenyl-1-o-tolylquinolin-4(1H)-one 
• 1258792-44-7 1-(4-fluorophenyl)-3-phenylquinolin-4(1H)-one 
• 1258792-45-8 1-(2,4-dichlorophenyl)-3-phenylquinolin-4(1H)-one 
• 1258792-46-9 1-(naphthalen-1-yl)-3-phenylquinolin-4(1H)-one 
• 1258792-47-0 1-(benzo[d][1,3]dioxol-5-yl)-3-phenylquinolin-4(1H)-one 

Relevant academic research and scientific papers

Rh-Catalyzed Chemoselective [4 + 1] Cycloaddition Reaction toward Diverse 4-Methyleneprolines

An efficient synthesis of 4-methyleneproline derivatives has been developed through an Rh-catalyzed [4 + 1] cycloaddition strategy using 3-methyleneazetidines and diazo compounds. The reaction proceeds under very mild conditions with a high degree of chemoselectivity, and competing experiments revealed that it is the preferred reaction, dominant over the C-H insertion, O-H insertion, and olefin cyclopropanation reactions which are commonly observed in Rh carbene chemistry. This method can incorporate the proline ester scaffold in pharmaceuticals and natural products. The intramolecular version of the reaction effectively provides proline-fused small to medium-sized tricyclic heterocycles. Gram-scale reactions, one-time addition of diazo compounds, and a minimum catalyst loading of 0.1 mol %, proceeded smoothly, implying their practicality.

Visible-Light-Promoted [3 + 2] Cycloaddition of 2H-Azirines with Quinones: Access to Substituted Benzo[f]isoindole-4,9-diones

A visible-light-promoteded [3 + 2] cycloaddition reaction of 2H-azirines with quinones has been developed under mild reaction conditions. The reaction provides a general and efficient strategy for the synthesis of the benzo[f]isoindole-4,9-diones scaffold

The intramolecular reaction of acetophenoneN-tosylhydrazone and vinyl: Br?nsted acid-promoted cationic cyclization toward polysubstituted indenes

In the presence of TsNHNH2, a Br?nsted acid-promoted intramolecular cyclization ofo-(1-arylvinyl) acetophenone derivatives was developed, leading to polysubstituted indenes with complexity and diversity in moderate to excellent yields. In sharp contrast with either the radical or carbene involved cyclization of aldehydicN-tosylhydrazone with vinyl, a cationic cyclization pathway was involved, whereN-tosylhydrazone served as an electrophile and alkylation reagent during this transformation.

Asymmetric Synthesis of 1,2-Dihydronaphthalene-1-ols via Copper-Catalyzed Intramolecular Reductive Cyclization

We describe a copper-catalyzed intramolecular reductive cyclization of easily accessible benz-tethered 1,3-dienes containing a ketone moiety. This process provided biologically active 1,2-dihydronaphthalene-1-ol derivatives in good yields with excellent enantio- and diastereoselectivity. Mechanistic investigations using density functional theory revealed that (Z)- and (E)-allylcopper intermediates formed in situ from the diene and copper catalyst undergo isomerization and selective intramolecular allylation of the (E)-allylcopper form of the major product through a six-membered boatlike transition state. The resulting products were further transformed to fully saturated naphthalene-1-ols by reactions of the olefin moiety.

Parecoxib sodium substituted impurity and preparation method thereof

The invention relates to a parecoxib sodium substituted impurity and a preparation method thereof. The preparation method comprises the following steps: carrying out a reaction on a compound with a structure represented by a formula I with hydroxylamine h

Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP

An efficient and user-friendly palladium(II) precatalyst, POxAP (post-oxidative-addition precatalyst), was identified for use in Fukuyama cross-coupling reactions. Suitable for storage under air, the POxAP precatalyst allowed reaction between thioesters and organozinc reagents with turnover numbers of ～90000. A series of 23 ketones were obtained with yields ranging from 53 to 99%. As proof of efficacy, an alternative approach was developed for the synthesis of a key precursor of the natural product isoprekinamycin.

A Remarkably Simple Hybrid Surfactant-NHC Ligand, Its Gold-Complex, and Application in Micellar Catalysis

A combination of an N-heterocyclic carbene (NHC) ligand and a structurally simple surfactant has been realized, the hybrid surfactant-NHC. The related gold complex was synthesized, fully characterized, and applied in catalysis. This remarkably simple strategy allows, in combination with a co-surfactant, the application of gold catalysis in water. Just merge it! The hybrid of a surfactant and an N-heterocyclic carbene (NHC) ligand is reported and applied for the synthesis of the derived gold complex (see scheme). The new resulting NHC-based metallosurfactant can interact with surfactants to form micelles and allows micellar catalysis for gold catalysis in water.

Substitution controlled functionalization of ortho -bromobenzylic alcohols via palladium catalysis: Synthesis of chromenes and indenols

An efficient domino Pd-catalyzed transformation of simple ortho-bromobenzyl tertiary alcohols to chromenes is presented. Their formation is believed to proceed via the formation of a five-membered palladacycle, which, in turn, involves in an intermolecular homocoupling with the second ortho- bromobenzyltertiary alcohol to yield the homo-biaryl bond followed by intramolecular C-O bond formation. Interestingly, when there is an allylic substituent on the benzylic carbon atom, a chemoselective switch was observed, which preferred intramolecular Heck coupling and gave indenols. Further, it has been confirmed that the tertiary alcohol functionality is indispensible to give the coupled products, whereas the use of primary/secondary benzylic alcohols furnished the simple carbonyl products via a possible reductive debromination followed by oxidation due to the availability of β-hydrogen(s).

TiCl4-catalyzed indirect anti-Markovnikov hydration of alkynes: Application to the synthesis of benzo[b]furans

(Chemical Equation Presented) An efficient methodology for the indirect anti-Markovnikov hydration of unsymmetrically substituted terminal and internal alkynes is based on TiCl4-catalyzed hydroamination reactions. Its application to ortho-alkynylhaloarenes, followed by a copper-catalyzed O-arylation, provides flexible access to substituted benzo[b]furans.

BICYCLIC IMIDAZOL DERIVATIVES AGAINST FLAVIVIRIDAE

Disclosed are compounds, compositions and methods for treatingFlaviviridae family virus infections.