872585-01-8Relevant academic research and scientific papers
Anti-inflammatory effects of an optimized PPAR-γ agonist via NF-κB pathway inhibition
Hong, Jongki,Ju, Zhiran,Jung, Jee H.,Kim, Eun La,Su, Mingzhi
, (2020)
In our previous study, a PPAR-γ agonist (+)-(R,E)-6a1 was elaborated as an anti-inflammatory lead. However, in silico analysis showed that (+)-(R,E)-6a1 lacks key hydrogen bonding with Tyr473 of PPAR-γ LBD (ligand binding domain). To facilitate
New compounds having PPAR-γ activity, and medical use thereof
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Paragraph 0206; 0207, (2020/04/01)
The present invention relates to a novel compound having PPAR-andgamma; activity and to a medical use thereof. According to the present invention, an exocyclic enone jasmonate derivative acting as a PPAR-andgamma; activator is synthesized by binding an an
Acceleration of the Morita-Baylis-Hillman reaction by a simple mixed catalyst system
Bugarin, Alejandro,Connell, Brian T.
supporting information; experimental part, p. 4638 - 4641 (2009/09/08)
(Chemical Equation Presented) By using a catalytic amount of 4-dimethylaminopyridine (DMAP) as a nucleophile in the presence of an equal amount of tetramethylethylenediamine (TMEDA) and MgI2, Morita-Baylis-Hillman adducts can be obtained in good to excellent yields from various aromatic and aliphatic aldehydes and cyclic enones/enoates at room temperature after convenient reaction times.
A practical preparation of 2-hydroxymethyl-2-cyclopenten-1-one by Morita-Baylis-Hillman reaction
Ito, Hisanaka,Takenaka, Yosuke,Fukunishi, Shouhei,Iguchi, Kazuo
, p. 3035 - 3038 (2007/10/03)
Tributylphosphine or dimethylphenylphosphine (1-5 mol%) catalyzed the Morita-Baylis-Hillman reaction of 2-cyclo-penten-1-one (1) with 1.2 equivalents of formalin proceeded nicely to give 2-hydroxymethyl-2-cyclopenten-1-one (2) within a short period and in
