87259-91-4Relevant academic research and scientific papers
Synthesis of indolo[2,3-a]pyrrolo[3,4-c]carbazoles by oxidative cyclization of bisindolylmaleimides with a rhodium(III)-copper(II) catalytic system
Witulski, Bernhard,Schweikert, Torsten
, p. 1959 - 1966 (2007/10/03)
A novel catalytic protocol for the synthesis of a series of indolo[2,3-a]pyrrplo[3,4-c]carbazoles based on the bimetallic system RhCl 3·3H2O and Cu(OAc)2·H 2O in the presence of molecular oxygen was investigated
Coupling reactions of indole-3-acetic acid derivatives. Synthesis of arcyriaflavin A
Bergman, Jan,Koch, Eva,Pelcman, Benjamin
, p. 2609 - 2614 (2007/10/03)
The bisindolesuccinic acid methyl ester 10 was obtained by an iodine-promoted coupling of the dianion 9. The diester was converted to the N-benzylimide 12, which was oxidatively cyclized to the indolo[2,3-a]pyrrolo[3,4-c]-carbazole 15. The diester 10 coul
Further indole derivatives with antiviral activity
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, (2008/06/13)
The present invention relates to indolopyrolocarbazole derivatives, to their use in methods of treatment or prophylaxis of at least one viral infection or cardiovascular diseases; and pharmaceutical formulations containing such derivatives.
SYNTHESIS OF A REBECCAMYCIN-RELATED INDOLOCARBAZOLE BY PALLADIUM(0) CATALYZED POLYANNULATION.
Saulnier, Mark G.,Frennesson, David B.,Deshpande, Milind S.,Vynas, Dinesh M.
, p. 7841 - 7844 (2007/10/02)
The assembly of the parent Indolocarbazole ring system, common to rebeccamycin and arcyriaflavin A, is efficiently accomplished by the discovery of a novel palladium(0)-catalyzed polyannulation reaction, wherein 4 bonds are formed in a single step from a simple monocyclic 1,3-diacetylene precursor.This chemistry further demonstrates the power of palladium(0) in the execution of complex synthetic organic chemistry, and also provides a novel approach to the synthesis of Indolocarbazole alkaloids, an increasingly important class of bioactive natural products.
A facile synthesis of staurosporine aglycone
Xie, Guojian,Lown, J. William
, p. 5555 - 5558 (2007/10/02)
A highly efficient method is described for the synthesis of staurosporine aglycone 3 from the readily available dibromomaleic acid in six steps.
Synthesis of the Indolocarbazole Natural Products Staurosporinone and Arcyriaflavin B
Hughes, Ian,Nolan, William P.,Raphael, Ralph A.
, p. 2475 - 2480 (2007/10/02)
Flexible synthetic routes involving double nitrene insertions are described leading to the indolocarbazole systems present in a growing group of natural products.The methods are exemplified by the total synthesis of two members of this group stauro
Synthesis of Indolopyrrolocarbazoles by Double Fischer Indolizations
Bergman, Jan,Pelcman, Benjamin
, p. 824 - 828 (2007/10/02)
A synthesis of indolopyrrolocarbazoles (16) based on a double Fisher indolization of the bis(phenylhydrazones) (10), employing polyphosphoric acid trimethylsilyl ester (PPSE) as the cyclization agent, is described.The bis(phenylhydrazones) (
COUPLING OF INDOLEACETIC ACID TRIANION OR METHYL INDOLEACETIC ACID DIANION. A BIOMIMETIC APPROACH TO INDOLOCARBAZOLE ALKALOIDS.
Bergman, J.,Pelcman, B.
, p. 4441 - 4444 (2007/10/02)
The bisindolesuccinic acid ester 8b was obtained as a mixture of diastereomers by iodine promoted coupling of the dianion 7b or via the trianion 7a.The diester was converted to the N-benzylimide 10 which was oxidatively cyclized to the indolopyrrol
NATURAL PRODUCT SYNTHESIS VIA CYCLOADDITIONS WITH N-SULFINYL DIENOPHILES
Weinreb, Steven M.,Garigipati, Ravi S.,Gainor, James A.
, p. 309 - 324 (2007/10/02)
Diels-Alder cycloadducts derived from N-sulfinyl dienophiles have been used for stereospecific preparation of acyclic unsaturated amines and in stereospecific syntheses of threo-sphingosine (31) and erythro sphingosine (32).Methodology based upon these cy
