872590-08-4Relevant academic research and scientific papers
Benzimidazole-5-sulfonamides as novel nonpeptide luteinizing hormone releasing hormone (LHRH) antagonists: Minimization of mechanism-based CYP3A4 inhibition
Hashimoto, Kentaro,Kataoka, Mikayo,Tatsuta, Miyuki,Yasoshima, Kayo,Yamamoto, Mako,Yura, Takeshi,Yamamoto, Noriyuki,Urbahns, Klaus,Gupta, Jang Bahadur,Yingfu
, p. 1314 - 1317 (2005)
Herein we report the development of novel, potent and non-peptide luteinizing hormone releasing hormone (LHRH) antagonists. The optimization towards derivatives free from mechanism-based CYP3A4 inhibition is described. The identification of a main metabol
