Benzimidazole-5-sulfonamides as novel nonpeptide luteinizing hormone releasing hormone (LHRH) antagonists: Minimization of mechanism-based CYP3A4 inhibition

DOI: 10.1248/cpb.53.1314

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1314 - 1317 (2005)

Update date:2022-08-04

Topics: Antagonists Mechanism-Based Inhibition Nonpeptide Minimization CYP3A4

Authors:

Hashimoto, Kentaro

Kataoka, Mikayo

Tatsuta, Miyuki

Yasoshima, Kayo

Yamamoto, Mako

Yura, Takeshi

Yamamoto, Noriyuki

Urbahns, Klaus

Gupta, Jang Bahadur

Yingfu Yingfu

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Article abstract of DOI:10.1248/cpb.53.1314

Herein we report the development of novel, potent and non-peptide luteinizing hormone releasing hormone (LHRH) antagonists. The optimization towards derivatives free from mechanism-based CYP3A4 inhibition is described. The identification of a main metabol

Full text of DOI:10.1248/cpb.53.1314

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