872614-36-3

Upstream product

• 22094-18-4 1,3-dibromo-2,2-dimethoxypropane 
• 16532-79-9 4-Bromophenylacetonitrile 

Downstream Products

• 1364663-42-2 methyl 1-(4-bromophenyl)-3-oxocyclobutane-1-carboxylate 
• 1361189-39-0 1-(4-bromo-phenyl)-3-difluoro-cyclobutanecarbonitrile 
• 1313441-70-1 2-(1-(4-bromophenyl)-3,3-dimethoxycyclobutyl)isoindoline-1,3-dione 
• 1313441-69-8 1-(4-bromophenyl)-3,3-dimethoxycyclobutanamine 
• 1313441-68-7 1-(4-bromophenyl)-3,3-dimethoxycyclobutanecarboxamide 
• 1199556-87-0 2-[1-(4-bromophenyl)-3-oxocyclobutyl]-1H-isoindole-1,3(2H)-dione 

Relevant academic research and scientific papers

NOVEL SUBSTITUTED PHENYL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS

Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (I) Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

NOVEL SUBSTITUTED CYCLOBUTYLBENZENE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS

Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

PICOLINAMIDE COMPOUNDS

The present disclosure is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, and solvates of the salt thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk of developing) and treatment

Substituted pyrazolo-piperazines as casein kinase 1 δ/ε inhibitors

The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.

OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION

The present invention relates to compound of formula (I) and pharmaceutically acceptable salt thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

INHIBITORS OF AKT ACTIVITY

The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.