87263-06-7

Upstream product

• 70056-19-8 diphenylmethyl 7-(2-thienylacetamido)-2-methylene-3-acetoxymethylceph-3-em-4-carboxylate 
• 80366-21-8 diphenylmethyl 7-(2-thienylacetamido)-2,3-dimethylenecepham-4-carboxylate 
• 80366-16-1 diphenylmethyl 7-(2-thienylacetamido)-2-methyl-3-formyloxymethylceph-2-em-4-carboxylate 
• 80366-17-2 diphenylmethyl 7-(2-thienylacetamido)-2-methyl-3-hydroxymethyl-ceph-2-em-4-carboxylate 

Downstream Products

• 80366-27-4 diphenylmethyl 7-amino-2α-methyl-3-(1-methyl-1H-tetrazol-5-yl)thiomethylceph-3-em-4-carboxylate 
• 80366-19-4 diphenylmethyl 7-(2-thienylacetamido)-2α-methyl-3-(1-methyl-1H-tetrazol-5-yl)thiomethylceph-3-em-4-carboxylate 
• 80377-40-8 4-(1,1-diphenylmethylcarbonyl)-7-(2-thienylacetamido)-2α-methyl-3-(1-methyl-1H-tetrazol-5-yl)thiomethylceph-3-em 1-oxide 
• 1609070-60-1 C₂₂H₂₁ClN₂O₃S 
• 1609070-59-8 C₂₈H₂₅ClN₂O₄S₂ 
• 80366-18-3 diphenylmethyl 7-(2-thienylacetamido)-2-methyl-3-(1-methyl-1H-tetrazol-5-yl)thiomethylceph-2-em-4-carboxylate 

Relevant academic research and scientific papers

2 - Substituted cephem compound-containing pharmaceutical composition

PROBLEM TO BE SOLVED: To provide a cephem compound which has a strong antimicrobial activity, in particular effective against various β-lactamase producing Gram negative bacteria, and a composition comprising the compound.SOLUTION: The present invention provides a pharmaceutical composition comprising a compound represented by formula (I), an ester at a carboxyl group, an amino-protected compound when the amino is present on a ring in the 7-side chain, or a pharmaceutically acceptable salt thereof.

2 SUBSTITUTED CEPHEM COMPOUNDS

The compounds of formula (I) of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

Synthesis of 2α-methyl- and 2β-methyl-3-(substituted methyl)cephalosporins, and 2,3-diexomethylenecepham

The stereoselective synthesis of 2α-methyl- and 2β-methyl-3-(substituted methyl)- cephalosporins via 2-methyl-3-formyloxymethylceph-2-em (5) and 2-methyl-3-acetoxymethylceph-2-em (16) from 2-methylene-3-acetoxymethylcephalosporin (1) is described. Reducti