87264-35-5Relevant articles and documents
A Formal Total Synthesis of Ipalbidine
Iida, Hideo,Watanabe, Yohya,Kibayashi, Chihiro
, p. 261 - 266 (2007/10/02)
The synthesis of 1,2,3,5,8,9-hexahydro-6-(4-methoxyphenyl)indolizin-7(6H)-one (5), a key intermediate in the synthesis of (+/-)-ipalbidine (3), is described.The 1,3-dipolar cycloaddition of the nitrone (9) to p-methoxy(allyl)benzene (8) proceeded highly r
FORMAL SYNTHESIS OF (+/-)-IPALBIDINE
Iida, Hideo,Watanabe, Yohya,Kibayashi, Chihiro
, p. 1195 - 1196 (2007/10/02)
1-Aza-3-(4-methoxyphenyl)bicyclononan-4-one, key intermediate to (+/-)-ipalbidine, was conveniently synthesized by intramolecular cyclization of the N-formylketone which was obtained via cycloaddition reaction of the cyclic nitrone.