87264-40-2

Upstream product

• 1001078-39-2 6-iodo-2,3,8,8a-tetrahydroindolizin-7(1H)-one 
• 5720-07-0 4-methoxyphenylboronic acid 
• 140-67-0 Estragole 
• 87264-35-5 trans-2,3,3a,4,5,6-hexahydro-2-(4-methoxybenzyl)pyrrolo-<1,2-b>isoxazole 
• 87264-38-8 1-formyl-2β-<(2R*)-hydroxy-3-(4-methoxyphenyl)propyl>pyrrolidine 
• 87264-36-6 2β-<(2R*)-hydroxy-(4-methoxyphenyl)propyl>pyrrolidine 
• 905717-35-3 2,3,8,8a-tetrahydroindolizin-7(1H)-one 

Downstream Products

• 73048-99-4 1-aza-3-(4-methoxyphenyl)bicyclo<4.3.0>nonan-4-one 
• 96658-16-1 7-hydroxy-6-(4-methoxyphenyl)indolizidine 
• 96658-17-2 6,7-dihydroxy-6-(4-methoxyphenyl)indolizidine 

Relevant academic research and scientific papers

Microwave-assisted Suzuki-Miyaura couplings on α-iodoenaminones

A systematic study of α-iodination and subsequent Suzuki-Miyaura couplings between non-attenuated enaminones and a wide range of aromatic boronic acids is reported. The microwave-assisted variant of this transformation furnished the α-arylenaminones in si

Copper-assisted palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids

Described herein is a palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids. The versatility of this method is that both electron-rich and electron-poor boronic acids can be coupled in high yields. A mixture of two Cu(II) ad

Copper-assisted palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids

Described herein is a palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids. The versatility of this method is that both electron-rich and electron-poor boronic acids can be coupled in high yields. A mixture of two Cu(II) ad

Palladium(II)-catalyzed direct arylation of enaminones using organotrifluoroborates

A Pd(II)-catalyzed reaction for the direct arylation of cyclic enaminones is reported. The reactivity of electron-rich, electron-poor, and sterically encumbered organotrifluoroborates was investigated. This reaction represents a unique use for organotrifluoroborates as coupling partners and discloses the utility of enaminones for direct-functionalization reactions. It provides immediate access to arylpiperidine, indolizidine, and quinolizidine scaffolds from the corresponding mono- and bicyclic, unattenuated enaminones. Copyright

A Formal Total Synthesis of Ipalbidine

The synthesis of 1,2,3,5,8,9-hexahydro-6-(4-methoxyphenyl)indolizin-7(6H)-one (5), a key intermediate in the synthesis of (+/-)-ipalbidine (3), is described.The 1,3-dipolar cycloaddition of the nitrone (9) to p-methoxy(allyl)benzene (8) proceeded highly r

FORMAL SYNTHESIS OF (+/-)-IPALBIDINE

1-Aza-3-(4-methoxyphenyl)bicyclononan-4-one, key intermediate to (+/-)-ipalbidine, was conveniently synthesized by intramolecular cyclization of the N-formylketone which was obtained via cycloaddition reaction of the cyclic nitrone.