87266-35-1

Basic information

• Product Name: 1H-Imidazole,1-(2-methyl-2-propenyl)-(9CI)
• Synonyms: 1H-Imidazole,1-(2-methyl-2-propenyl)-(9CI)
• CAS NO: 87266-35-1
• Molecular Formula: C7H10N2
• Molecular Weight: 122.1677
• Product Categories: AMINETERTIARY
• Mol File: 87266-35-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Imidazole,1-(2-methyl-2-propenyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole,1-(2-methyl-2-propenyl)-(9CI)(87266-35-1)
• EPA Substance Registry System: 1H-Imidazole,1-(2-methyl-2-propenyl)-(9CI)(87266-35-1)

Safety Data

• Hazardous Substances Data: 87266-35-1(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 513-42-8 3-hydroxy-2-methyl-1-propene 
• 563-47-3 3-Chloro-2-methylpropene 

Relevant articles and documents

Phosphabarrelene-modified Rh-catalysts: A new and selective route towards hydroxy-functionalized bicyclic imidazoles via tandem reactions

8-Hydroxy-6-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine was formed selectively in high yields from N-(β-methallyl)imidazole by a tandem hydroformylation-cyclization sequence, representing a novel one-pot catalytic synthesis of bicyclic imidazole deriv

Palladium-Catalyzed Dehydrative Cross-Coupling of Allylic Alcohols and N-Heterocycles Promoted by a Bicyclic Bridgehead Phosphoramidite Ligand and an Acid Additive

A mild and efficient dehydrative cross-coupling reaction between allylic alcohols and N-heterocycles using palladium catalysis is reported. A bicyclic bridgehead phosphoramidite (briphos) ligand together with Pd(dba)2 is a highly efficient catalyst, and an acid additive involved in the rate-determining step promotes the catalytic cycle. The coupling reaction of allylic alcohols with N-heterocycles including imidazoles, benzimidazoles, and triazole proceeds under mild reaction conditions with high yields using Pd/briphos and pentafluorophenol.

An improved and convenient procedure for the synthesis of 1-substituted imidazoles

1-Protected imidazoles, such as 1-acetyl- and 1-benzoylimidazoles, react with various halides, such as benzyl, allyl, α-keto, and alkyl halides, to give 1-protected-3-substituted imidazolium salts in high yields. The resultant imidazolium salts are easily deprotected by treatment with water or alcohols to give the corresponding 1-substituted imidazoles in excellent yields. In this reaction the yields of 1-substituted imidazoles vary with the kinds of halides used and/or with the protecting groups, and the yields increase in the following order: benzyl halides≥allyl halides~α-keto halides>alkyl halides, and acetyl≥benzoyl>ethoxycarbonyl>diethoxymethyl>trimethylsilyl>tosyl.