872693-22-6Relevant academic research and scientific papers
In vitro study of isoflavones and isoflavans as potent inhibitors of human 12- and 15-lipoxygenases
Mascayano, Carolina,Espinosa, Victoria,Sepulveda-Boza, Silvia,Hoobler, Eric K.,Perry, Steve
, p. 317 - 325 (2013)
In this study, we have investigated 16 isoflavone and isoflavan derivatives as potential inhibitors of human lipoxygenase (platelet 12-lipoxygenase, reticulocyte 15-lipoxygenase-1, and epithelial 15-lipoxygenase-2). The flavonoid baicalein, a known lipoxygenase inhibitor, was used as positive control. Four compounds, 6,7-dihydroxy-3′-chloroisoflavone (1c), 7-hydroxy-8-methyl-4′-chloroisoflavan (5a), 7,8-dihydroxy-4′-methylisoflavan (5b), and 7,8-dihydroxy-3′-methylisoflavan (5c), were effective inhibitors of 12-lipoxygenases and 15-lipoxygenase-1 with IC50's i values in the range of 0.3-3 μm.
