872703-72-5

Upstream product

• 872703-52-1 2-benzyl-N-[(1S,2R)-2-hydroxy-indan-1-yl]acrylamide 
• 5669-19-2 2-Benzyl-2-propenoic acid 
• 7480-35-5 (1S,2R)-1-amino-2-indanol 

Downstream Products

• 1202901-89-0 (S)-2-benzyl-3-(4-bromobenzylamino)-2-hydroxy-N-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)propanamide 
• 1202901-80-1 (S)-2-benzyl-3-(benzylamino)-2-hydroxy-N-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)propanamide 
• 882435-40-7 {(1S)-1-[N'-(3-bromo-benzyl)-N'-[(2S)-2-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-3-phenyl-propyl]-hydrazinocarbonyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester 
• 872703-69-0 1 

Relevant academic research and scientific papers

HIV protease inhibitors

Compounds of the formula (I): Wherein R1, R2, X and N are as defined in the specification; E is N, CH; A1 and A" are terminal groups as defined in the specification. The compounds have utility as HIV-I protease inhibitors.

A new class of HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold

Novel HIV-1 protease inhibitors encompassing a tertiary alcohol as part of the transition-state mimicking unit have been synthesized. Variation of the P1′-P3′ residues and alteration of the tertiary alcohol absolute stereochemistry a