1313726-28-1

Basic information

• Product Name: 7-(chloromethyl)-[1,2,4]triazolo[1,5-a]pyridine
• CAS NO: 1313726-28-1
• Molecular Weight: 167.598
• Mol File: 1313726-28-1.mol
• Article Data: 2

Chemical Properties

• Density: 1.42±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 7-(chloromethyl)-[1,2,4]triazolo[1,5-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(chloromethyl)-[1,2,4]triazolo[1,5-a]pyridine(1313726-28-1)
• EPA Substance Registry System: 7-(chloromethyl)-[1,2,4]triazolo[1,5-a]pyridine(1313726-28-1)

Safety Data

• Hazardous Substances Data: 1313726-28-1(Hazardous Substances Data)

Upstream product

• 1313726-27-0 N-(4-(chloromethyl)pyridin-2-yl)-N'-hydroxyformimidamide 
• 872706-97-3 4-(chloromethyl)pyridin-2-amine 

Relevant articles and documents

Discovery of (S)-1-(1-(Imidazo[1,2- a ]pyridin-6-yl)ethyl)-6-(1-methyl-1 H -pyrazol-4-yl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer

HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.