87271-22-5

Upstream product

• 15149-10-7 2-(4-methylphenoxy)ethanol 
• 124-63-0 methanesulfonyl chloride 
• 18800-34-5 1-bromo-2-(4'-methylphenoxy)ethane 
• 2386-52-9 silver methanesulfonate 

Downstream Products

• 702-18-1 1-Fluor-2-(p-methyl)phenoxyethan 
• 1304773-42-9 1-(2-(2-fluoroethoxy)ethoxy)-4-methylbenzene 
• 1304773-33-8 (S)-1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione 
• 1304773-37-2 (S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)azetidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile 
• 1304773-40-7 (S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile 
• 1304773-43-0 1-(bromomethyl)-4-(2-(2-fluoroethoxy)ethoxy)benzene 
• 1304773-27-0 (S)-1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)azetidin-1-ylsulfonyl)indoline-2,3-dione 

Relevant academic research and scientific papers

CuCl2-Mediated Oxidative Intramolecular α-Arylation of Ketones with Phenolic Nucleophiles via Oxy-Allyl Cation Intermediates

α-Functionalization of ketones in an umpolung fashion can be achieved by nucleophilic addition to the oxy-allyl cation intermediate. However, applicable carbon nucleophiles are limited to ones with high nucleophilicity. Additionally, introduction of a lea

Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: Introduction of a hydrophilic group increases potency in a whole cell assay

A series of isatin analogs containing a hydrophilic group, including a pyridine ring, ethylene glycol group, and a triazole ring, have been synthesized, and their inhibition potency for caspase-3 was measured both in vitro (i.e., recombinant enzyme) and in whole cells (HeLa cells). The analogs having a hydrophilic group, including 12, 13, 16, 38, and 40, have dramatically increased activity in vitro and in HeLa cells compared to the corresponding unsubstituted N-phenyl isatin analogs.

On the Intermediary Existence of Gaseous Ethylen Fluoronium Ions

The long-sought ethylen fluoronium ion (2) is generated as an intermediate in the dissociative ionization of 1-fluoro-2-(p-methyl)phenoxy ethane (4).However, prior to collisionally induced dissociation 2 undergoes ring-opening, associated with hydrogen migration, to form 1-fluoroethyl cation (3).Other decomposition pathways of the molecular ions of 4 involve (i) direct formation of 3 via a combination of C-O cleavage (loss of ArO(*)) and hydrogen migration (18percent) and (ii) complete positional loss of the α- and β-methylene hydrogen atoms (34percent).The remaining 48percent of the m olecular ions of 4 dissociate via anchimeric assistance of the fluorine in the elimination of ArO(*), thus giving rise to the formation of 2. - Keywords: Fluoronium Ions, Neighbouring Group Participation, Gaseous Ions, Collisional Activation, Mass Spectrometry