872726-33-5

Usage

Uses

Used in Pharmaceutical Industry:
CP 100263 Dihydrochloride Hydrate is used as a pharmaceutical agent for testosterone replacement therapy. It serves as an NK-1 neurokinin receptor antagonist, which can help in managing conditions related to testosterone deficiency by modulating the activity of the neurokinin receptors.
Used in Research Applications:
In research settings, CP 100263 Dihydrochloride Hydrate is used as a tool compound to study the role of NK-1 neurokinin receptors in various physiological and pathological processes. This can aid in understanding the receptor's function and its potential as a target for therapeutic intervention in different diseases.
The provided materials highlight its use in testosterone replacement therapy and its chemical properties as a white solid, which are crucial for its applications in the pharmaceutical and research industries.

Upstream product

• 872726-32-4 (2R,3R)-3-(2-Methoxy-benzylamino)-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1187890-34-1 C₂₄H₃₂N₂O₃ 
• 139190-15-1 3-(2-methoxybenzylamino)-2-phenylpyridine 
• 13292-87-0 dimethyl sulfide borane 
• 239437-21-9 Methanesulfonic acid (4S,5S)-5-tert-butoxycarbonylamino-4-dibenzylamino-5-phenyl-pentyl ester 
• 239437-20-8 ((1S,2S)-2-Dibenzylamino-5-hydroxy-1-phenyl-pentyl)-carbamic acid tert-butyl ester 
• 239437-22-0 (2S,3S)-3-Dibenzylamino-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 187679-58-9 (2S,3S)-3-Amino-1-tert-butoxycarbonyl-2-phenylpiperidine 
• 187679-57-8 tert-butyl (2S,3S)-3-({[2-(methyloxy)phenyl]methyl}amino)-2-phenylpiperidinecarboxylate 
• 145148-38-5 (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-(3-chloro-propyl)-4-phenyl-azetidin-2-one 
• 145148-36-3 (S)-2-((R)-Amino-phenyl-methyl)-5-chloro-pentanoic acid methyl ester 
• 145212-91-5 methyl (2R,3S)-cis-2-phenylpiperidine-3-carboxylate 
• 145148-37-4 (R)-1-(tert-Butyl-dimethyl-silanyl)-4-phenyl-azetidin-2-one 
• 37088-65-6 (3R)-4-phenyl-2-azetidinone 

Relevant academic research and scientific papers

Diastereoconvergent synthesis of trans -5-hydroxy-6-substituted-2- piperidinones by addition-cyclization-deprotection process

A diastereoselective one-pot approach to access trans-5-hydroxy-6- substituted-2-piperidinones by an addition-cyclization-deprotection process has been developed, in which the stereogenic center at the C-6 position was solely controlled by α-OTBS group. The utility of this transformation is demonstrated by the asymmetric synthesis of the enantiomer of (-)-CP-99,994.

Asymmetric synthesis of (2S,3R)-(-)-epi-CP-99,994 using sulfinimine-derived anti-2,3-diamino esters

A differentially protected C-3 N-sulfinyl, C-2 N,N-(diphenylmethylene) 2,3-diamino ester was employed in the synthesis of the amino piperidine (2S,3R)-(-)-epi-CP-99,994. Key steps in the synthesis included the chemoselective hydrolysis of the C-2 N,N-(dip

Synthesis of (+)-CP-99,994 via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H diamination of terminal olefin

(Chemical Equation Presented) This paper describes an asymmetric synthesis of the potent substance P receptor antagonist (+)-CP-99,994 from 4-phenyl-1-butene via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H diamination. 2009 American Chemical So

A concise and practical catalytic asymmetric synthesis of (-)-CP-99,994 and (-)-L-733,061

A concise and practical catalytic asymmetric synthesis of (-)-CP-99,994 and (-)-L-733,061 was achieved. Key features involve the Pd-catalyzed asymmetric allylic amination and the ring-closing metathesis as key steps.

Enantioselective synthesis of NK-1 receptor antagonists (+)-CP-99,994 and (+)-CP-122,721

An enantioselective total synthesis of NK-1 receptor antagonists, (+)-CP-99,994 and (+)-CP-122,721, is described. The key steps are diastereoselective addition of vinyllithium to a chiral benzaldehyde oxime ether and diastereoselective borane reduction of

Stereoselective synthesis of (+)-CP-99,994: A substance P non-peptide antagonist

A highly stereoflexible total synthesis of (+)-CP-99,994 is achieved starting, from (S)-serine, key steps being a diastereoselective Grignard addition, a one-pot reductive protection of an azide, and one-pot oxidative Wittig olefination.

Preparation of substituted piperidines

Substituted piperidines and related compounds of the formula STR1 wherein R1 and R2 are herein defined are disclosed.

3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use

The present invention relates to novel 3-aminopiperidine derivatives and related nitrogen containing heterocyclic compounds, and specifically, to compounds of the formula STR1 wherein R1, R2, R3, R4, R5/su

3-Aminopiperidine derivatives and related nitrogen containing heterocycles

The present invention relates to novel 3-aminopiperidine derivatives and related nitrogen containing heterocyclic compounds, and specifically, to compounds of the formula wherein R1, R2, R3, R4, R5, R6, R7, Rsu