87273-74-3

Basic information

• Product Name: N-(4-phenylthiazol-2-yl)-3-aminocrotonamide
• Synonyms: N-(4-phenylthiazol-2-yl)-3-aminocrotonamide
• CAS NO: 87273-74-3
• Molecular Weight: 259.332
• Mol File: 87273-74-3.mol

Chemical Properties

• CAS DataBase Reference: N-(4-phenylthiazol-2-yl)-3-aminocrotonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-phenylthiazol-2-yl)-3-aminocrotonamide(87273-74-3)
• EPA Substance Registry System: N-(4-phenylthiazol-2-yl)-3-aminocrotonamide(87273-74-3)

Safety Data

• Hazardous Substances Data: 87273-74-3(Hazardous Substances Data)

Upstream product

• 2911-22-0 6-methyl-4-oxo-2-thioxo-3,4-dihydro-2H-1,3-oxazine 
• 87273-73-2 6-Methyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-[1,3]oxazin-4-one 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 87273-76-5 3-phenyl-5-methyl-7H-thiazolo<3,2-a>pyrimidin-7-one 
• 5039-09-8 2-acetamide-4-phenyl-1,3-thiazole 
• 87273-75-4 3‐oxo‐N‐(4‐phenylthiazol‐2yl)butanamide 

Relevant articles and documents

S-PHENACYLATION OF 6-METHYL-4-OXO-2-THIO-2,3-DIHYDRO-4H-1,3-OXAZINE AND THE RING TRANSFORMATION OF THE S-PHENACYLATED COMPOUND

1,3-oxazine 1 reacted with phenacyl bromide in water using sodium hydroxide as a base to give S-phenacylated derivative 2, but the homogeneous conditions such as NaH in THF or NaOMe in methanol caused the base-induced cycloreversion of 1, resulting in the formation of thiocyanate 3.For the purpose of the intramolecular transformation to pyrimidine-fused heterocycle 11, 2 was treated with ammonia in refluxing ethanol, but gave amidamine 6 while 8 was obtained with ammonium acetate in refluxing acetic acid.Although the direct ring closure failed, the target 11 was finally synthesized by the cyclodehydration of ketamide 7 with phosphorus pentoxide at 250 deg C.