87274-96-2

Upstream product

• 5537-66-6 1,4-dimethyl-3,3-diphenyl-pyrrolidin-2-ylideneamine 
• 6293-01-2 2,2-diphenyl-3-methyl-4-(dimethylamino)-butyronitrile 
• 17268-75-6 (+/-)-2-imino-1,4-dimethyl-3,3-diphenylpyrrolidine hydrochloride 
• 86-29-3 Diphenylacetonitrile 
• 108-14-5 2-chloro-1-dimethylaminopropane 
• 14198-53-9 4-(benzyl-methyl-amino)-3-methyl-2,2-diphenyl-butyronitrile 
• 87274-93-9 (+/-)-4-(N-carbomethoxy-N-methylamino)-2,2-diphenyl-3-methylbutyronitrile 

Relevant academic research and scientific papers

Synthesis and anticonvulsant screening of 3,3-diphenyl-2-pyrrolidone derivatives

Six derivatives of 3,3-diphenyl-2-pyrrolidone were synthesized and screened for anticonvulsant activity. The synthetic route involved a mono-N-demethylation of an intermediate N,N-dimethylaminonitrile with methyl chloroformate followed by cleavage of the carbamate group. Of the six derivatives, (±)-2-imino-1,5-dimethyl-3,3-diphenylpyrrolidine hydrochloride was effective in protecting mice against maximal electroshock (MES)-induced seizures at a 30-mg/kg dose level.