108-14-5

Basic information

• Product Name: 2-chloropropyldimethylamine
• Synonyms: 2-chloropropyldimethylamine;2-CHLORO-N,N-DIMETHYL-1-PROPYLAMINE;2-Chloro-1-dimethylaminopropane;2-chloro-n,n-dimethyl propylamine;2-Chloro-N,N-dimethyl-1-propanamine;2-Chloro-N,N-dimethylpropan-1-amine;1-Propanamine, 2-chloro-N,N-dimethyl- (9ci);Einecs 203-554-3
• CAS NO: 108-14-5
• Molecular Formula: C5H12ClN
• Molecular Weight: 121.60848
• EINECS: 203-554-3
• Mol File: 108-14-5.mol

Chemical Properties

• Boiling Point: 81.1°Cat760mmHg
• Flash Point: 2.9°C
• Appearance: /
• Density: 0.934g/cm³
• Vapor Pressure: 83mmHg at 25°C
• Refractive Index: 1.432
• PKA: 8.56±0.28(Predicted)
• CAS DataBase Reference: 2-chloropropyldimethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloropropyldimethylamine(108-14-5)
• EPA Substance Registry System: 2-chloropropyldimethylamine(108-14-5)

Safety Data

• Hazardous Substances Data: 108-14-5(Hazardous Substances Data)

Usage

Uses

Used in Agricultural Chemicals Production:
2-chloropropyldimethylamine is used as a key intermediate for the synthesis of agricultural chemicals, contributing to the development of effective pest control agents and other crop protection products.
Used in Dye Manufacturing:
In the dye industry, 2-chloropropyldimethylamine is utilized as an intermediate, playing a crucial role in the production of various dyes that are used in coloring textiles, plastics, and other materials.
Used in Pharmaceutical Production:
2-chloropropyldimethylamine is employed as a chemical intermediate in the synthesis of pharmaceuticals, aiding in the creation of new drugs and improving the efficacy of existing medications.
Used as a Corrosion Inhibitor:
2-chloropropyldimethylamine is used as a corrosion inhibitor in various industrial applications, helping to protect metal surfaces from degradation and extending the lifespan of equipment and structures.
Used as an Emulsifying Agent:
2-chloropropyldimethylamine functions as an emulsifying agent, facilitating the mixing of immiscible substances such as oil and water, which is essential in the formulation of various products in the food, cosmetic, and pharmaceutical industries.
Used in the Synthesis of Quaternary Ammonium Compounds:
As a raw material, 2-chloropropyldimethylamine is used in the synthesis of quaternary ammonium compounds, which have applications in disinfectants, sanitizers, and other antimicrobial products.
Used in Surfactant Synthesis:
2-chloropropyldimethylamine is commonly employed in the synthesis of surfactants, which are essential in the production of detergents, cleaners, and other products that require the reduction of surface tension.
Used in Specialty Chemicals Production:
2-chloropropyldimethylamine also serves as a chemical intermediate in the production of specialty chemicals, which are used in a variety of applications, including coatings, adhesives, and sealants.
It is important to handle 2-chloropropyldimethylamine with care due to its classification as a hazardous substance, as it can cause skin and eye irritation and respiratory issues if inhaled. Proper safety measures should be taken during its use and storage to minimize potential health risks.

InChI:InChI=1/C5H12ClN/c1-5(6)4-7(2)3/h5H,4H2,1-3H3

Upstream product

• 926-63-6 N,N-dimethylaminopropane 
• 67-66-3 chloroform 
• 7782-50-5 chlorine 
• 4584-49-0 (2-chloropropyl)dimethylamine hydrochloride 
• 53309-35-6 (2-chloro-1-methyl-ethyl)-dimethyl-amine 
• 15521-18-3 2-(dimethylamino)propan-1-ol 
• 108-16-7 1-methyl-2-N,N-dimethylaminoethanol 
• 56-23-5 tetrachloromethane 

Downstream Products

• 60-87-7 10-[2-(dimethylamino)propyl]phenothiazine 
• 303-14-0 isopromethazine 
• 412033-15-9 1,3-dimethyl-4-phenyl-hexahydro-azepine-4-carbonitrile 
• 5844-21-3 benzoic acid-[N'-(β-dimethylamino-isopropyl)-hydrazide] 
• 92043-41-9 dimethyl-[2-(2-[1,3,4]oxadiazol-2-yl-phenoxy)-propyl]-amine 
• 125-79-1 (R,S)-2,2-diphenyl-4-dimethylaminopentanenitrile 
• 6293-01-2 2,2-diphenyl-3-methyl-4-(dimethylamino)-butyronitrile 
• 15521-18-3 2-(dimethylamino)propan-1-ol 
• 187737-37-7 propene 
• 926-63-6 N,N-dimethylaminopropane 
• 1822-45-3 1,2-bis(dimethylamino)propane 
• 124-40-3 dimethyl amine 
• 5443-48-1 1-(N,N-dimethylamino)-2,3-dichloropropane 
• 1485-36-5 N,N-dimethyl-2-methyl-2-phenoxyaminoethane 

Relevant articles and documents

COMPOSITIONS AND METHODS FOR THE TREATMENT OF SEVERE PAIN

The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of severe pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of chronic pain, generalized pain disorders, leukemia, cancer, chronic pain, chemotherapy induced pain, epilepsy, migraine, neuropathic pain, post herpetic neuralgia, neuralgia, pain, drug addiction, detoxification of drugs, Alzheimer's disease, multiple sclerosis, multiple sclerosis, restless legs syndrome (RLS), cluster headache, depression, fibromyalgia, amyotrophic lateral sclerosis (ALS), convulsions, partial seizures, mood-stabilizing agent and bipolar disorder.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF SEVERE PAIN

The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for the treatment of severe pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of chronic pain, generalized pain disorders, leukemia, cancer, chronic pain, chemotherapy induced pain, epilepsy, migraine, neuropathic pain, post herpetic neuralgia, neuralgia, pain, drug addiction, detoxification of drugs, Alzheimer's disease, multiple sclerosis, multiple sclerosis restless legs syndrome (RLS), cluster headache, depression, fibromyalgia, amyotrophic lateral sclerosis (ALS), convulsions, partial seizures, mood-stabilizing agent and bipolar disorder.

Fused pyridazine compounds and their pharmaceutical use

Fused pyridazine compounds STR1 wherein R1, R2, R3 and R4 are the same or different and respectively hydrogen, a halogen, hydroxy, nitro, amino, cyano, trifluoromethyl, and alkyl, an alkoxy or an alkanoylamino; one of Ra and Rb is a group of the formula wherein R5 and R6 are the same or different and respectively hydrogen, an alkyl, a phenylalkyl or a substituted phenylalkyl or a group forming a heterocycle together with the adjacent nitrogen atom and Y stands for a straight- or branched-chain alkylene which may have hydroxy group as a substituent on the chain, and the other is hydrogen, or both of Ra and Rb are the same or different and respectively a group of the formula wherein R5 and R6 are of the same meanings as defined above; W is =CH-- or =N; X is CH2, S, SO, SO2 or O; and the bond designated by a broken line in its part stands for a single bond or a double bond, or their pharmaceutically acceptable salts or hydrates and their pharmaceutical use. Said compounds possess stimulating effects on phagocytosis of leukocytes and macrophages, restorative effects on leukopenia, protective effects against infection, antitumor actions and the like and thus they are useable for the prophylaxis or therapy of human diseases accompanied by immunodeficiency.

PHENOTHIAZINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Phenothiazine derivatives of formula: STR1 in which Y is hydrogen or halogen, R 1 and R 2, which may be identical or different, denote alkyl, cycloalkyl-alkyl, hydroxyalkyl or acetyloxyalkyl radicals or form, together with the nitrogen atom to which they are attached, an optionally substituted, saturated or partially unsaturated 4-to 7-membered heterocycle; and either X is oxygen, sulphur or: N-R 4, R is cycloalkyl, phenyl or--CH 2 R 3, R 3 is H, alkyl (1 to 5 C), alkenyl or alkynyl (2 to 4 C), cycloalkyl (3 to 6 C), phenyl, substituted phenyl or a heterocyclic radical, R 4 is H or--CN, except that X is not oxygen if, simultaneously, R 3 is H or alkyl, R. sub.1 and R 2 are alkyl or NR 1 R 2 forms an unsubstituted heterocycle, and Y is H; or X is: N-R 4 and R 4 forms, with R and the neighbouring atoms, an optionally substituted imidazolyl or imidazolinyl radical or a hexahydrobenzimidazolyl radical, in their isomeric forms and mixtures thereof and their acid addition salts are useful as analgesics and diuretics.

Modification of methadone synthesis process step

Alkylation of diphenylacetonitrile in methadone synthesis is carried out in presence of sodium hydroxide and DMF.