872782-70-2Relevant academic research and scientific papers
Synthesis, characterization and evaluation of benzylidene analogues as a new class of potential antioxidant agents
Malhotra, Manav,Sharma, Rajiv,Sanduja, Mohit,Hans, Pankhuri,Sharma, Sagun,Deep, Aakash
experimental part, p. 363 - 368 (2012/09/07)
Seventeen analogues of benzylidene were synthesized and evaluated for in vitro hydrogen peroxide scavenging activity. The structure of the newly synthesized compounds were confirmed by elemental and spectral (IR, 1H-NMR, 13C-NMR) studies. The antioxidant activity of the titled compounds was evaluated. Compounds: 4h - N′-[2-amino-3- (morpholinomethyl)benzylidene]isonicotinohydrazide, 4p 7-(4-{2-amino-3-[(2- isonicotinoylhydrazono)methyl]benzyl}piperazin-1-yl)-1-cyclopropyl-6-fluoro-4- oxo-1,4-dihydroquinoline-3-carboxylic acid and 4q 7-(4-{2-amino-3-[(2 isonicotinoylhydrazono)methyl]benzyl}piperazin-1-yl)-1-ethyl-6, 8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid were the most active compounds with significant hydrogen peroxide scavenging activity.
