87282-27-7Relevant academic research and scientific papers
Design and synthesis of 4,5-diaryl/heteroarylthiophene-2-carboxylic acid derivatives and evaluation of their biological activities
Arasavelli, Ananda Mohan,Raghava, Ganapavarapu Sharma Veera,Vidavalur, Siddaiah
, p. 9 - 14 (2017/03/01)
Synthesis, characterization and biological activity of novel 4,5-diaryl/heteroaryl thiophene-2-carboxylic acid derivatives are described. Aryl/heteroaryl esters were converted to substituted thiophene esters via a Vilsmeier-Haack reaction, which were then hydrolyzed to 4,5-diaryl/heteroaryl thiophene-2-carboxylic acid derivatives 8a-h. All products were characterized by 1H NMR, 13C NMR, IR and MS. Antibacterial activity of the synthesized compounds against two Gram-positive and two Gram-negative bacteria, as well as their anticancer activity against PC-3 cell line (human prostate cancer cell lines) were evaluated.
