872857-74-4Relevant academic research and scientific papers
5-Carba-pterocarpens: A new scaffold with anti-HCV activity
Fernandes, Talita de A.,Costa, Paulo R. R.,Manvar, Dinesh,Basu, Amartya,Kaushik-Basu, Neerja,Domingos, Jorge L. O.,Nichols, Daniel Brian
, p. 33 - 38 (2018/05/15)
The synthesis of a series of 5-carba-pterocarpens derivatives involving the cyclization of α-aryl-α-tetralones is described. Several compounds demonstrated potent activity and selectivity in vitro against HCV replicon reporter cells. The best profile in H
Synthesis and biological evaluation of α-aryl-α-tetralone derivatives as hepatitis C virus inhibitors
Manvar, Dinesh,Fernandes, Talita De A.,Domingos, Jorge L.O.,Baljinnyam, Erdenechimeg,Basu, Amartya,Junior, Eurides F.T.,Costa, Paulo R.R.,Kaushik-Basu, Neerja
supporting information, p. 51 - 54 (2015/02/19)
The synthesis of a novel series of 1-carba-isoflavanones through the α-arylation of α-tetralones is described. Several of these compounds demonstrated potent activity and selectivity in-vitro against HCV replicon reporter cells. Compound 10 (LQB-314) exhibited the best profile being active and selective in both replicon reporter cells (IC50 1.8 μM, SI > 111 and IC50 4.3 μM, SI > 46 in Huh7/Rep-Feo1b and Huh7.5-FGR-JC1-Rluc2A, respectively). Compound 3 (LQB-307) was the more potent and selective for Huh7.5-FGR-JC1-Rluc2A replicon reporter cells (IC50 1.5 μM, SI > 101.4).
Synthesis of 5-carbapterocarpens by α-arylation of tetralones followed by one-pot demethylation/cyclization with BBr3
Fernandes, Talita De A.,Domingos, Jorge L. O.,Da Rocha, Luiza I. A.,De Medeiros, Sabrina,Najera, Carmen,Costa, Paulo R. R.
, p. 1314 - 1320 (2014/03/21)
5-Carbapterocarpens, one of them displaying estrogenic activity, were prepared from α-aryltetralones in high yields through a one-pot, BBr 3-promoted O-demethylation and cyclization sequence. The key α-aryltetralone intermediates were obtained
Synthesis of 5-Carbapterocarpens by α-Arylation of Tetralones Followed by One-Pot Demethylation/Cyclization with BBr3
Fernandes, Talita De A.,Domingos, Jorge L. O.,Da Rocha, Luiza I. A.,De Medeiros, Sabrina,Njera, Carmen,Costa, Paulo R. R.
, p. 1314 - 1320 (2015/10/05)
5-Carbapterocarpens, one of them displaying estrogenic activity, were prepared from α-aryltetralones in high yields through a one-pot, BBr3-promoted O-demethylation and cyclization sequence. The key α-aryltetralone intermediates were obtained b
Tetracyclic compounds as estrogen ligands
-
Page/Page column 11; 16, (2010/02/15)
This invention provides estrogen receptor modulators having the structure: wherein R1, R2, R3, R4, Q, n, R8, R9, R10, and R11 have been defined in the specification; o
