872858-54-3Relevant academic research and scientific papers
Pyrazole CCK1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free-Wilson additivity
Sehon, Clark,McClure, Kelly,Hack, Michael,Morton, Magda,Gomez, Laurent,Li, Lina,Barrett, Terrance D.,Shankley, Nigel,Breitenbucher, J. Guy
, p. 77 - 80 (2006)
High-throughput screening revealed compound 1 as a potent antagonist of the CCK1 receptor. Here, we disclose the synthesis of combinatorial libraries by solid-phase synthesis on Kenner 'safety catch' resin. Additive QSAR models were used to determine a lack of consistent additive SAR within the matrix.
