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4-((R)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 872866-27-8 Structure
  • Basic information

    1. Product Name: 4-((R)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide
    2. Synonyms: 4-((R)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide
    3. CAS NO:872866-27-8
    4. Molecular Formula:
    5. Molecular Weight: 480.566
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 872866-27-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-((R)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-((R)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide(872866-27-8)
    11. EPA Substance Registry System: 4-((R)-3-(morpholin-4-yl)-3-oxo-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide(872866-27-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 872866-27-8(Hazardous Substances Data)

872866-27-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 872866-27-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,2,8,6 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 872866-27:
(8*8)+(7*7)+(6*2)+(5*8)+(4*6)+(3*6)+(2*2)+(1*7)=218
218 % 10 = 8
So 872866-27-8 is a valid CAS Registry Number.

872866-27-8Relevant articles and documents

APOPTOSIS-INDUCING AGENTS

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, (2014/03/22)

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti apoptotic Bcl-xL protein.

CHEMICAL COMPOUNDS

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, (2012/02/15)

The present invention relates to compounds of Formula (I): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit Bcl-2 and/or Bcl-XL activities and may be used for the treatment of cancer.

ARYLSULFONAMIDE COMPOUNDS

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Page/Page column 31; 33-34, (2008/12/05)

The invention relates generally to small molecules that mimic the biological activity of certain peptides and proteins, to compositions containing them and to their use. In particular, the invention relates to compounds of the general formula (I) that mim

Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo

Wendt, Michael D.,Shen, Wang,Kunzer, Aaron,McClellan, William J.,Bruncko, Milan,Oost, Thorsten K.,Ding, Hong,Joseph, Mary K.,Zhang, Haichao,Nimmer, Paul M.,Ng, Shi-Chung,Shoemaker, Alexander R.,Petros, Andrew M.,Oleksijew, Anatol,Marsh, Kennan,Bauch, Joy,Oltersdorf, Tilman,Belli, Barbara A.,Martineau, Darlene,Fesik, Stephen W.,Rosenberg, Saul H.,Elmore, Steven W.

, p. 1165 - 1181 (2007/10/03)

Development of a rationally designed potentiator of cancer chemotherapy, via inhibition of Bcl-XL function, is described. Lead compounds generated by NMR screening and directed parallel synthesis displayed sub-μM binding but were strongly deactivated in the presence of serum. The dominant component of serum deactivation was identified as domain III of human serum albumin (HSA); NMR solution structures of inhibitors bound to both Bcl-X L and HSA domain III indicated two potential optimization sites for separation of affinities. Modifications at both sites resulted in compounds with improved Bcl-XL binding and greatly increased activity in the presence of human serum, culminating in 73R, which bound to Bcl-XL with a Ki of 0.8 μM. In a cellular assay 73R reversed the protection afforded by Bcl-XL overexpression against cytokine deprivation in FL5.12 cells with an EC50 of 0.47 μM. 73R showed little effect on the viability of the human non small cell lung cancer cell line A549. However, consistent with the proposed mechanism, 73R potentiated the activity of paclitaxel and UV irradiation in vitro and potentiated the antitumor efficacy of paclitaxel in a mouse xenograft model.

N-acylsulfonamide apoptosis promoters

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, (2008/06/13)

N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.

N-Acylsulfonamide apoptosis promoters

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, (2008/06/13)

N-Benzoyl arylsulfonamides having the formula Are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.

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