87293-44-5

Basic information

• Product Name: 7-Chloroquinoline-8-carboxylic acid
• Synonyms: 7-Chloro-8-quinolinecarboxylic acid;7-Chloroquinoline-8-carboxylic acid
• CAS NO: 87293-44-5
• Molecular Formula: C10H6ClNO2
• Molecular Weight: 207.61314
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates
• Mol File: 87293-44-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Chloroquinoline-8-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloroquinoline-8-carboxylic acid(87293-44-5)
• EPA Substance Registry System: 7-Chloroquinoline-8-carboxylic acid(87293-44-5)

Safety Data

• Hazardous Substances Data: 87293-44-5(Hazardous Substances Data)

Usage

Uses

7-Chloro-8-quinolinecarboxylic acid is an impurity of Quinclorac (Q670300).

Upstream product

• 78941-93-2 7-Chloro-8-methylquinoline 
• 87-60-5 3-chloro-2-methylbenzenamine 
• 2148-56-3 2-chloro-6-aminobenzoic acid 
• 56-81-5 glycerol 

Relevant articles and documents

Dihaloquinolinic acid intermediate and preparation method thereof

The invention relates to the field of herbicide synthesis, and particularly discloses a dihaloquinolinic acid intermediate and a preparation method thereof, wherein the structure of the dihaloquinolinic acid intermediate is as shown in a formula (2). The method is characterized in that in the presence of a catalyst, a compound with a structure as shown in a formula (1) is used as a raw material, carboxylic acid is used as a solvent, oxygen-containing gas is used as an oxidant, and an oxidation reaction is performed, wherein the catalyst is one or more of a cobalt metal compound, a manganese metal compound and a vanadium metal compound, and in the formula (1) and the formula (2), X is halogen. According to the method, a large amount of waste acid and waste water can be prevented from beinggenerated, environmental protection is achieved, and the three-waste treatment cost is greatly reduced; and the method has the advantages of mild reaction conditions, simple post-treatment and high product purity and yield, and is very suitable for industrial production.

Preparation method of quinclorac

The invention relates to the field of herbicides, and discloses a preparation method of quinclorac, which comprises: 1) adopting an N-hydroxyphthalimide compound and azodiisobutyronitrile as catalysts, adopting oxygen as an oxidizing agent, and oxidizing 7-chloro-8-methylquinoline to obtain 7-chloro-8-quinoline carboxylic acid; and 2) by taking azodiisobutyronitrile as a catalyst, carrying out chlorination reaction on 7-chloro-8-quinoline carboxylic acid and chlorine to obtain 3,7-dichloro-8-quinoline carboxylic acid. By means of the method disclosed by the invention, the generation of a largeamount of waste acid and wastewater in a synthesis process can be reduced, and the product yield of quinclorac can be increased.

Catalytic formation of ketones from unactivated esters through rhodium chelation-assisted C-O bond activation

A new method for building aryl aryl ketones containing heterocyclic rings through chelation-assisted C-O bond activation catalyzed by a rhodium complex has been developed. In this reaction, methyl quinoline-8-carboxylate, methyl quinoxaline-5-carboxylate, and their derivatives were reacted with an excess amount of a substituted phenyl boronic acid in the presence of a rhodium(I) complex to give substituted phenyl(quinolin-8-yl)methanone, phenylquinoxalin-5- ylmethanone, and their derivatives in medium to high yields. The current method offers a highly favorable synthetic pathway to efficiently build related drugs with an 8-benzoylquinoline core structure. This method may prove especially valuable for medicinal chemists for the late-stage introduction of versatile ketone moieties into complex scaffolds for diversity-oriented synthetic strategies.