87294-97-1

Basic information

• Product Name: 4-(MORPHOLIN-4-YLCARBONYL)BENZONITRILE
• Synonyms: 4-(MORPHOLIN-4-YLCARBONYL)BENZONITRILE;4-Isocyanobenzoic acid morpholide
• CAS NO: 87294-97-1
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.24
• Mol File: 87294-97-1.mol
• Article Data: 23

Chemical Properties

• Melting Point: 141-142 °C
• Boiling Point: 429.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• PKA: -2.26±0.20(Predicted)
• CAS DataBase Reference: 4-(MORPHOLIN-4-YLCARBONYL)BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(MORPHOLIN-4-YLCARBONYL)BENZONITRILE(87294-97-1)
• EPA Substance Registry System: 4-(MORPHOLIN-4-YLCARBONYL)BENZONITRILE(87294-97-1)

Safety Data

• Hazardous Substances Data: 87294-97-1(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 105-07-7 4-cyanobenzaldehyde 
• 32792-64-6 2,4-dinitrophenyl 4-cyanobenzoate 
• 104-85-8 para-methylbenzonitrile 
• 619-65-8 4-cyanobenzoic Acid 
• 6068-72-0 4-cyanobenzoyl chlorIde 
• 3058-39-7 4-iodobenzonitrile 
• 144-62-7 oxalic acid 
• 874-89-5 4-Cyanobenzyl alcohol 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 127580-92-1 (4-bromophenyl)(morpholino)methanone 
• 198978-33-5 4-iodobenzoyl cyanide 
• 201230-82-2 carbon monoxide 
• 138467-41-1 C₁₄H₈N₂O₃S 

Downstream Products

• 675618-10-7 (4-(methylthio)phenyl)(morpholino)methanone 
• 160491-40-7 [(4-cyanophenyl)morpholinomethylene]tetracarbonyliron⁽⁰⁾ 

Relevant articles and documents

NaI-mediated oxidative amidation of benzyl alcohols/aromatic aldehydes to benzamides via electrochemical reaction

In this research, we have developed a mild electrochemical process for oxidative amidation of benzyl alcohols/aromatic aldehydes with cyclic amines into the corresponding benzamides. This electroorganic synthetic method proceeds using NaI as a redox mediator under ambient temperature in undivided cell, providing more than 25 examples of amide products in moderate to good yields. The benefits of this reaction include one-pot synthesis, open air condition, proceed in aqueous media and no requirement of external conducting salt, base and oxidant.

Nickel-Catalyzed Reversible Functional Group Metathesis between Aryl Nitriles and Aryl Thioethers

We describe a new functional group metathesis between aryl nitriles and aryl thioethers. The catalytic system nickel/dcype is essential to achieve this fully reversible transformation in good to excellent yields. Furthermore, the cyanide- and thiol-free reaction shows high functional group tolerance and great efficiency for the late-stage derivatization of commercial molecules. Finally, synthetic applications demonstrate its versatility and utility in multistep synthesis.

The Hofmann reaction involving annulation of: O -(pyridin-2-yl)aryl amides selectively and rapidly leads to potential photocatalytically active 6 H -pyrido[1,2- c] quinazolin-6-one derivatives

A highly efficient PIFA-mediated Hofmann reaction of o-(pyridin-2-yl)aryl amides has been developed to selectively and rapidly construct various potential photocatalytically active 6H-pyrido[1,2-c]quinazolin-6-one derivatives. The use of a nontoxic and ec