87298-40-6Relevant academic research and scientific papers
3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors
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, (2008/06/13)
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease
X=Y-ZH SYSTEMS AS POTENTIAL 1,3-DIPOLES. PART 21 ACTIVATION OF THE ZH PROTON IN IMINES.
Grigg, Ronald,Donegan, Gregory,Gunaratne, H. Q. Nimal,Kennedy, Deirdre A.,Malone, John F.,et al.
, p. 1723 - 1746 (2007/10/02)
Imines, RCH=N-ZH, possessing a range of ZH groups (Z=CHCOPh, CHCOSR, CHCONHR, CHP(O)(OEt)2, 2-CH-pyridyl, 2-CH-thiazolyl, and 9-fluorenyl) undergo thermal 1,2-prototropy generating azomethine ylides stereospecifically.The intermediate azomethine ylides un
