872983-84-1Relevant academic research and scientific papers
Engineering D-amino acid containing novel protease inhibitors using catalytic site architecture
Annedi, Subhash C.,Biabani, Farooq,Poduch, Ewa,Mannargudi, Baskar M.,Majumder, Kanchana,Wei, Lianhu,Khayat, Reza,Tong, Liang,Kotra, Lakshmi P.
, p. 214 - 236 (2007/10/03)
The mechanism of proteolysis by serine proteases is a reasonably well-understood process. Typically, a histidine residue acting as a general base deprotonates the catalytic serine residue and the hydrolytic water molecule. We disclose here, the use of an
