873-42-7 Usage
Uses
3,5-Dichloro-2-pyrazinamine is used in the synthesis of pyrazinones as inhibitors of protein kinases, which play a key role in the progression of cancer. It is also used in the synthesis of N-substituted pyrazines by tandem reaction ofo-aminohalopyrazines with isothiocyanates.
Check Digit Verification of cas no
The CAS Registry Mumber 873-42-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,7 and 3 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 873-42:
(5*8)+(4*7)+(3*3)+(2*4)+(1*2)=87
87 % 10 = 7
So 873-42-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H3Cl2N3/c5-2-1-8-4(7)3(6)9-2/h1H,(H2,7,8)
873-42-7Relevant articles and documents
Efficient Halogenation of 2-Aminopyrazine
Grima, Josep,Lizano, Enric,Pujol, M. Dolors
, p. 2000 - 2003 (2019/10/22)
2-Aminopyrazine was halogenated with NIS, NCS, and NBS under different reaction conditions. Chlorination and bromination were achieved with good yields by using acetonitrile as the solvent. However, iodination was only obtained in poor yields. Undoubtedly, the best conditions for both mono-and dihalogenation were the use of NBS, acetonitrile, and microwave assistance for short periods. 3,5-Dibromo-2-Aminopyrazine is an excellent functionalized starting material for the synthesis of nitrogen heterocycles.