874-31-7

Basic information

• Product Name: 2-Amino-5-chloro-3-methoxypyrazine
• Synonyms: 2-Amino-5-chloro-3-methoxypyrazine;5-Chloro-3-methoxypyrazin-2-ylamine;5-chloro-3-methoxypyrazin-2-amine
• CAS NO: 874-31-7
• Molecular Formula: C₅H₆ClN₃O
• Molecular Weight: 159.575
• Mol File: 874-31-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 128-131 °C
• Boiling Point: 271.113 °C at 760 mmHg
• Flash Point: 117.765 °C
• Appearance: /
• Density: 1.398 g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.01±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-5-chloro-3-methoxypyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-chloro-3-methoxypyrazine(874-31-7)
• EPA Substance Registry System: 2-Amino-5-chloro-3-methoxypyrazine(874-31-7)

Safety Data

• Hazardous Substances Data: 874-31-7(Hazardous Substances Data)

Usage

General Description

2-Amino-5-chloro-3-methoxypyrazine is a chemical compound that belongs to the chemical class known as Pyrazines. Pyrazines are compounds containing a pyrazine, which is a six-membered aromatic heterocycle made from two nitrogen atoms and four carbon atoms. The specificity of 2-Amino-5-chloro-3-methoxypyrazine lies in its substitution with the mentioned functional groups (amino, chloro, and methoxy) attached to the pyrazine ring. These functional groups can significantly influence the compound's properties and reactivity. It might be used in a range of industrial, pharmaceutical, or research applications, though information about its specific potential uses may be limited and require specialized knowledge and safety measures during handling.

InChI:InChI=1/C5H6ClN3O/c1-10-5-4(7)8-2-3(6)9-5/h2H,1H3,(H2,7,8)

Upstream product

• 124-41-4 sodium methylate 
• 873-42-7 3,5-dichloro-pyrazin-2-ylamine 
• 76537-18-3 3-bromo-5-chloro-2-aminopyrazine 

Downstream Products

• 173253-74-2 5-dimethylamino-N-(5-chloro-3-methoxy-2-pyrazinyl)-1-naphthalenesulphonamide 

Relevant articles and documents

PYRIDINYL AND PYRAZINYL-(AZA)INDOLSULFONAMIDES

The present invention relates to pyridinyl and pyrazinyl-(aza)indolsulfonamides having GPR17 modulator activity. The compounds have utility in the treatment of a variety of GPR17-associated disorders.

N-heterocyclyl sulphonamide derivatives and their use as endothelin antagonists

The invention concerns pharmaceutically useful N-heterocyclyl sulphonamide derivatives, their pharmaceutically acceptable salts, processes for their manufacture, their use for antagonising one or more actions of endothelin in a human or other warm-blooded animal, their use in methods of treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role.

New non-peptide endothelin-a receptor antagonists: Synthesis, biological properties, and structure-activity relationships of 5-(dimethylamino)-N- pyridyl-, -N-pyrimidinyl-, -N-pyridazinyl-, and -N-pyrazinyl-1- naphthalenesulfonamides

Use of automated synthesis led to the discovery of several 6-membered nitrogen heterocycles as replacements for the N-isoxazolyl substituent present in the 1-naphthalenesulfonamide endothelin-A (ETA) antagonist 5- (dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide (BMS 182874). In each of these heterocycles, a small substituent such as halogen para to the position of attachment to the sulfonamide nitrogen atom was found to be advantageous for ETA receptor affinity. Of these heterocycles, 2- pyrazines offered the greatest scope for improving receptor affinity. Optimization of the substituents at the 3- and 5-positions in the pyrazine ring led to potent, ET(A)-selective compounds such as 5-(dimethylamino)-N- (5-chloro-3-methoxy-2-pyrazinyl)-1-naphthalenesulfonamide (7m, ET(A) pIC50 8.1). When dosed orally at 10 mg/kg to conscious, normotensive rats infused with big ET-1, compounds such as 7m showed significant inhibition of the pressor response with a duration of effect lasting for the 5-h course of the experiment.