873006-01-0

Usage

Uses

Used in Pharmaceutical Industry:
4-Formyl-3-iodobenzotrifluoride, 2-Iodo-alpha,alpha,alpha-trifluoro-p-tolualdehyde is used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its versatile reactivity allows it to be a key intermediate in the production of diverse organic compounds, contributing to the development of new and effective pharmaceutical agents.
Used in Fine Chemicals Industry:
4-Formyl-3-iodobenzotrifluoride, 2-Iodo-alpha,alpha,alpha-trifluoro-p-tolualdehyde is used as a key intermediate in the manufacturing of fine chemicals, dyes, and pigments. Its unique properties and reactivity make it a valuable component in the production of these specialty chemicals.
Used in Medicinal Chemistry and Drug Discovery:
4-Formyl-3-iodobenzotrifluoride, 2-Iodo-alpha,alpha,alpha-trifluoro-p-tolualdehyde has potential applications in the field of medicinal chemistry and drug discovery. Its versatile reactivity and unique properties make it a promising candidate for the development of new pharmaceutical agents and the advancement of drug discovery efforts.

Upstream product

• 455-24-3 4-trifluoromethylbenzoic acid 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 95725-04-5 N,N-diethyl-4-(trifluoromethyl)benzamide 
• 873005-49-3 (2-iodo-4-(trifluoromethyl)phenyl)methanol 
• 61500-87-6 methyl 2-Amino-4-(trifluoromethyl)benzoate 
• 54507-44-7 2-iodo-4-(trifluoromethyl)benzoic acid 
• 402-13-1 2-amino-4-trifluoromethylbenzoic acid 
• 1383707-89-8 N,N-diethyl-2-iodo-4-(trifluoromethyl)benzamide 
• 1259323-42-6 2-iodo-4-trifluoromethyl-benzonitrile 
• 1192931-87-5 4,4-dimethyl-2-(2-iodo-4-trifluoromethylphenyl)-2-oxazoline 

Downstream Products

• 873006-03-2 1-(2-iodo-4-trifluoromethylphenyl)ethanol 
• 873005-49-3 (2-iodo-4-(trifluoromethyl)phenyl)methanol 

Relevant academic research and scientific papers

Iodolopyrazolium Salts: Synthesis, Derivatizations, and Applications

The synthesis of iodolopyrazolium triflates via an oxidative cyclization of 3-(2-iodophenyl)-1H-pyrazoles is described. The reaction is characterized by a broad substrate scope, and various applications of these novel cyclic iodolium salts acting as useful synthetic intermediates are demonstrated, in particular in site-selective ring openings. This was finally applied to generate derivatives of the anti-inflammatory drug celecoxib. Their application as highly active halogen-bond donors is shown as well.

F- Nucleophilic-Addition-Induced [3 + 2] Annulation: Direct Access to CF3-Substituted Indenes

An efficient [3 + 2] annulation of (2,2-difluorovinyl)-2-iodoarenes and internal alkynes was developed for the synthesis of 1-(trifluoromethyl)-1H-indenes. The success of this strategy hinges upon a well-balanced process for the generation of two transient reactive species, specifically trifluoroethylsilver and alkenylpalladium intermediates, in the same molecule, as well as a smooth transmetalation step, which delicately joins together these two different metallic intermediates.

Phosphine/palladium-catalyzed syntheses of alkylidene phthalans, 3-deoxyisoochracinic acid, isoochracinic acid, and isoochracinol

In this study we used sequential catalysis-PPh3-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization-to construct complex functionalized alkylidene phthalans rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael-Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid, isoochracinic acid, and isoochracinol.

NAPHTHYLACETIC ACIDS

The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.