873006-01-0

Basic information

• Product Name: 4-Formyl-3-iodobenzotrifluoride, 2-Iodo-alpha,alpha,alpha-trifluoro-p-tolualdehyde
• Synonyms: 2-Iodo-4-(trifluoromethyl)benzaldehyde 97%;4-Formyl-3-iodobenzotrifluoride, 2-Iodo-alpha,alpha,alpha-trifluoro-p-tolualdehyde;2-iodo-4-trifluoromethylbenzaldehyde;2-Iodo-4-(trifluoromethyl)benzaldehyde97%
• CAS NO: 873006-01-0
• Molecular Formula: C₈H₄F₃IO
• Molecular Weight: 300.0164396
• Mol File: 873006-01-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Formyl-3-iodobenzotrifluoride, 2-Iodo-alpha,alpha,alpha-trifluoro-p-tolualdehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Formyl-3-iodobenzotrifluoride, 2-Iodo-alpha,alpha,alpha-trifluoro-p-tolualdehyde(873006-01-0)
• EPA Substance Registry System: 4-Formyl-3-iodobenzotrifluoride, 2-Iodo-alpha,alpha,alpha-trifluoro-p-tolualdehyde(873006-01-0)

Safety Data

• Hazardous Substances Data: 873006-01-0(Hazardous Substances Data)

Usage

General Description

4-Formyl-3-iodobenzotrifluoride, also known as 2-Iodo-alpha,alpha,alpha-trifluoro-p-tolualdehyde, is a chemical compound with the molecular formula C8H4F3IO. It is a derivative of fluorobenzaldehyde and is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. 4-Formyl-3-iodobenzotrifluoride, 2-Iodo-alpha,alpha,alpha-trifluoro-p-tolualdehyde is known for its versatile reactivity, serving as a key intermediate in the production of diverse organic compounds. It is also utilized in the manufacturing of fine chemicals, dyes, and pigments. Additionally, it has potential applications in the field of medicinal chemistry and drug discovery, contributing to the development of new and effective pharmaceutical agents.

Upstream product

• 402-13-1 2-amino-4-trifluoromethylbenzoic acid 
• 54507-44-7 2-iodo-4-(trifluoromethyl)benzoic acid 
• 61500-87-6 methyl 2-Amino-4-(trifluoromethyl)benzoate 
• 873005-49-3 (2-iodo-4-(trifluoromethyl)phenyl)methanol 
• 1259323-42-6 2-iodo-4-trifluoromethyl-benzonitrile 
• 1192931-87-5 4,4-dimethyl-2-(2-iodo-4-trifluoromethylphenyl)-2-oxazoline 
• 95725-04-5 N,N-diethyl-4-(trifluoromethyl)benzamide 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 1383707-89-8 N,N-diethyl-2-iodo-4-(trifluoromethyl)benzamide 

Downstream Products

• 873006-03-2 1-(2-iodo-4-trifluoromethylphenyl)ethanol 
• 873005-49-3 (2-iodo-4-(trifluoromethyl)phenyl)methanol 

Relevant articles and documents

Iodolopyrazolium Salts: Synthesis, Derivatizations, and Applications

The synthesis of iodolopyrazolium triflates via an oxidative cyclization of 3-(2-iodophenyl)-1H-pyrazoles is described. The reaction is characterized by a broad substrate scope, and various applications of these novel cyclic iodolium salts acting as useful synthetic intermediates are demonstrated, in particular in site-selective ring openings. This was finally applied to generate derivatives of the anti-inflammatory drug celecoxib. Their application as highly active halogen-bond donors is shown as well.

Phosphine/palladium-catalyzed syntheses of alkylidene phthalans, 3-deoxyisoochracinic acid, isoochracinic acid, and isoochracinol

In this study we used sequential catalysis-PPh3-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization-to construct complex functionalized alkylidene phthalans rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael-Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid, isoochracinic acid, and isoochracinol.

Molybdenum(0)-promoted carbonylative cyclization of o-haloaryland β-haloalkenylimine derivatives by oxidative addition of a carbon(sp 2)-halogen bond: Preparation of two types of γ-lactams

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